Figure 1

Family pedigrees, linkage analysis/homozygosity mapping, and mutation data. A) Pedigrees of five Saudi families segregating with autosomal recessive prelingual profound hearing loss. B) Linkage analysis showing LOD scores of 3.3 on chromosome 17 and 2.7 on chromosome 21 for families SS16 and KT1, indicating linkage to MYO15A and TMPRSS3 genes, respectively. Homozygosity mapping with GT console is shown for TRIC and LHFPL5 as genes of interest for families TA12 and SS3, respectively. For family SS17, homozygosity mapping with CNAG shows the region of homozygosity on chromosome 9 where TMC1 resides. C) Sequencing chromatogram of wild type, heterozygous and mutant alleles of respective deafness genes for a normal control, a carrier and affected member of each of the families.