The occurrence of germline BRCA1 and BRCA2sequence alterations in Slovenian population

BMC Medical Genetics

Table 7 Incidence of BRCA1 or BRCA2 mutations among different sub-groups of Slovenian families with breast and ovarian cancer.

Sub-group	BA	BC	BD	1B+1O	MoreO+1B	Only O
No. of mutation positive families (%)*
BRCA1 positive	10/19 (53%)	14/21 (67%)	2/7 (29%)	8/32 (25%)	6/7 (86%)	4/14 (29%)
BRCA2 positive	1/19 (5%)	2/21 (10%)	2/7 (29%)	3/32 (9%)	0/7 (0%)	1/14 (7%)

*number of positive families/number of all tested families in the group (the proportion of positive families). Group B (families with one or more cases of breast and at least one ovarian cancer) was further subdivided into sub-groups: BA - families with at least one ovarian cancer and at least two breast cancers diagnosed under the age of 50; BC - families with at least one ovarian cancer and at least two breast cancers, one of them diagnosed under the age of 50; BD - families with at least one ovarian cancer and at least two breast cancers all of them diagnosed beyond the age of 50; 1B+1O - families with only one ovarian cancer and one breast cancer in the family or only one affected individual in the family, but having both types of cancer at the same time; more O+1B - families with at least two ovarian cancers and only one breast cancer; only O - families with at least two ovarian cancers and no breast cancer.

ISSN: 1471-2350