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Table 6 Incidence of BRCA1 or BRCA2 mutations among different groups of Slovenian families defined according to family history.

From: The occurrence of germline BRCA1 and BRCA2sequence alterations in Slovenian population

Group

A

B

C

D

E

MBR

No. of mutation positive families (%)*

BRCA1 positive

18/77 (23%)

42/100 (42%)

8/75 (11%)

0/21 (0%)

2/24(8%)

0/25 (0%)

BRCA2 positive

10/77 (13%)

8/100 (8%)

6/75 (8%)

1/21 (5%)

0/24(0%)

1/25 (4%)

  1. *number of positive families/number of all tested families in the group (the proportion of positive families). Group A - families with two or more cases of breast cancer including at least two cases with the disease onset under the age of 50 and with no ovarian cancer. Group B - families with one or more cases of breast and at least one ovarian cancer. Group C - families with two or more cases of breast cancer including one case diagnosed before the age of 50 and with no ovarian cancer. Group D - families with two or more cases of breast cancer all of them diagnosed beyond the age of 50 and with no ovarian cancer. Group E - families with a single case of breast cancer diagnosed at the age under 40 years. Group MBR - families with a single male breast cancer. Bilateral breast cancers were considered as two separate cases of cancer.
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BMC Medical Genetics

ISSN: 1471-2350

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