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Table 4 Association of T266M with baseline data in Non-Hispanic White Look AHEAD participants

From: ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

 

TT

TM

MM

Pvalue

 

Mean (95% CI)

Mean (95% CI)

Mean (95% CI)

 

n males/n females

461/500

428/417

93/101

-

Triglycerides (mmol/L)

1.99 (1.93, 2.06)

1.87 (1.81, 1.94)

1.75 (1.63, 1.89)

0.002

Cholesterol (mmol/L)

4.91 (4.85, 4.96)

4.84 (4.78, 4.90)

4.79 (4.66, 4.91)

0.120

LDL-cholesterol (mmol/L)

2.78 (2.73, 2.82)

2.77 (2.72, 2.83)

2.75 (2.65, 2.86)

0.937

HDL-cholesterol (mmol/L)

1.05 (1.04, 1.07)

1.05 (1.05, 1.12)

1.09 (1.05, 1.12)

0.178

BMI (kg/m 2 )

35.94 (35.90, 35.97)

35.89 (35.85, 35.93)

35.97 (35.89, 36.05)

0.101

Weight (lbs)

100.71 (100.22, 101.19)

100.31 (99.80, 100.83)

101.10 (100.03, 102.18)

0.331

Waist Circumference (cm)

115.08 (114.61, 115.55)

114.91 (114.40, 115.41)

115.77 (114.72, 116.82)

0.346

Glucose (mmol/L)

8.44 (8.30, 8.59)

8.32 (8.17, 8.47)

8.19 (7.89, 8.51)

0.269

HbA1c

7.22 (7.16, 7.29)

7.13 (7.02, 7.20)

7.08 (6.95, 7.23)

0.067

SBP (mm/Hg)

129.18 (128.06, 130.30)

128.68 (127.48, 129.88)

126.85 (124.41, 129.34)

0.243

DBP (mm/Hg)

69.45 (68.89, 70.01)

69.15 (68.55, 69.76)

68.43 (67.20, 69.68)

0.327

Triglyceride (mmol/L)

Following removal of E40K Carriers

1.99 (1.92, 2.06)

(n = 889)

1.88 (1.81, 1.95)

(n = 775)

1.73 (1.60, 1.88)

(n = 182)

0.002

Triglycerides (mmol/L)

Subjects not taking lipid-lowering medication

1.95 (1.86, 2.05)

(n = 416)

1.82 (1.74, 1.93)

(n = 344)

1.66 (1.48, 1.85)

(n = 75)

0.01

  1. Data presented is mean (95% confidence intervals). Lipid data and blood pressure are adjusted for age, gender, study site, BMI, smoking, statins, diuretics, diabetes drugs, insulin, other lipid drugs, alcohol, menopause, HRT use. Anthropometric data are adjusted for age, gender, study site, smoking, statins, diuretics, diabetes drugs, insulin, other lipid drugs, alcohol, menopause, HRT use. Adjusted P values using an additive model of inheritance are presented.