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Table 3 Association of E40K with baseline data in Non-Hispanic White Look AHEAD participants

From: ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

 

EE

EK

Pvalue

 

Mean (95% CI)

Mean (95% CI)

 

n males/n females

934/934

40/42

-

Triglycerides (mmol/L)

1.94 (1.90, 1.99)

1.61 (1.44, 1.80)

0.001

Cholesterol (mmol/L)

4.86 (4.82, 4.90)

4.88 (4.69, 5.08)

0.889

LDL-cholesterol (mmol/L)

2.77 (2.73, 2.80)

2.87 (2.70, 3.04)

0.237

HDL-cholesterol (mmol/L)

1.05 (1.04, 1.06)

1.10 (1.05, 1.16)

0.081

BMI (kg/m 2 )

35.90 (35.87, 35.93)

35.91 (35.78, 36.03)

0.940

Weight (kg)

100.55 (100.21, 100.90)

101.51 (99.88, 103.17)

0.264

Waist Circumference (cm)

115.03 (114.69, 115.37)

116.73 (115.11, 118.37)

0.043

Glucose (mmol/L)

8.38 (8.28, 8.49)

8.02 (7.56, 8.51)

0.154

HbA1c

7.18 (7.14, 7.23)

7.00 (6.79, 7.22)

0.113

SBP (mm/Hg)

129.12 (128.31, 129.93)

124.88 (121.23, 128.64)

0.031

DBP (mm/Hg)

69.38 (68.98, 69.79)

67.55 (65.71, 69.43)

0.062

Triglycerides (mmol/L) on subjects not receiving lipid lowering medication

1.91 (1.85, 1.98)

(n = 771)

1.54 (1.31, 1.80)

(n = 36)

0.007

  1. Data presented is mean (95% confidence intervals). Lipid data and blood pressure are adjusted for age, gender, study site, BMI, smoking, statins, diuretics, diabetes drugs, insulin, other lipid drugs, alcohol, menopause, HRT use. Anthropometric data are adjusted for age, gender, study site, smoking, statins, diuretics, diabetes drugs, insulin, other lipid drugs, alcohol, menopause, HRT use. Adjusted P values using a dominant model of inheritance are presented.