ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

Table 2 Look AHEAD genotype frequencies of ANGPTL4 E40K and T266M by ethnic group

*ANGPTL4*variant	Genotype	Non-Hispanic White Americans			African American			Hispanic			Pvalue
		n	%	MAF	n	%	MAF	n	%	MAF	p1	p2	p3
E40K	118 G > A
EE	GG	1868	95.8		418	99.8		129	95.6
EK/KK	GA/AA	82/0	4.2	0.021	1/0	0.2	0.001	5/1	4.4	0.027	< 0.001	0.551	< 0.001
T266M	rs1044250
TT	CC	961	48.1		242	56.0		63	45.0
TM	CT	845	42.2		164	34.0		61	43.6
MM	TT	194	9.7	0.31	26	6.0	0.25	16	11.4	0.33	< 0.001	0.403	0.007

p1; Non-Hispanic whites vs. African Americans, p2; Non-Hispanic whites vs. Hispanics, p3; African Americans vs. Hispanics.