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Table 2 Risk of dyspepsia according to 5-HTTLPR genotypes

From: Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population

 

FD, total (n = 53)

 

EPS (n = 39)1

 

PDS (n = 42)1

 
 

OR

(95%CI)

P

uncorrected (corrected)

OR

(95%CI)

P

uncorrected (corrected)

OR

(95%CI)

P

uncorrected (corrected)

5-HTTLPR genotype

         

SS

1

reference

 

1

reference

 

1

reference

 

SL

1.75

(0.96-3.19)

0.672

(1.000)

1.33

(0.65-2.73)

0.443

(0.886)

*2.24

(1.16-4.32)

0.017

(0.033)

LL

2.12

(0.59-7.59)

0.250

(0.499)

2.50

(0.69-9.10)

0.164

(0.328)

3.02

(0.83-11.06)

0.094

(0.188)

Recessive model

         

SS vs. SL+LL

1.79

(1.01-3.18)

0.472

1.46

(0.75-2.87)

0.268

*2.32

(1.23-4.37)

0.009

  1. 1Twenty eight subjects are simultaneously classified EPS and PDS phenotype.
  2. FD, functional dyspepsia; EPS, epigastric pain syndrome; PDS, postprandial distress syndrome;
  3. OR, sex- and age-adjusted odds ratio, vs. 646 controls, by a multiple logistic regression model; CI, confidence interval.
  4. * Significant P < 0.05
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BMC Medical Genetics

ISSN: 1471-2350

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