Table 1 Neovascular AMD Patient Clusters Defined by Phenotypic and Genotypic Risk Characteristics
Cluster % (N = 253) | Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | F Statisti | P Value |
|---|---|---|---|---|---|---|
| Â | n = 71 | n = 84 | n = 56 | n = 42 | c | Â |
| Â | 28.1 | 33.2 | 22.1 | 16.6 | Â | Â |
Phenotypic Patient Characteristics | ||||||
History of High Blood Pressure (%) | 74.6 | 100.0 | 42.9 | 0.0 | 95.97 | <.001 |
History of High Cholesterol (%) | 100.0 | 45.2 | 1.8 | 28.6 | 89.68 | <.001 |
BMI (± SD) | 27.8 ± 4.7 | 26.4 ± 4.1 | 24.9 ± 4.5 | 26.8 ± 4.2 | 4.58 | .004 |
Mean Age (± SD) | 70.7 ± 8.4 | 74.5 ± 6.5 | 73.6 ± 6.9 | 73.9 ± 7.3 | 3.74 | .012 |
Decades of Alcohol Consumption (± SD) | 3.1 ± 2.2 | 3.2 ± 2.2 | 3.1 ± 2.2 | 3.8 ± 2.1 | 1.10 | .351 |
Male Sex (%) | 35.2 | 44.0 | 44.6 | 45.2 | .605 | .613 |
Mean Smoking in Total Pack Years (± SD) | 25.4 ± 30.8 | 28.7 ± 31.4 | 25.3 ± 35.2 | 26.8 ± 33.4 | .18 | .910 |
Genotypic Patient Characteristics | ||||||
HTRA1 rs1049331 | ||||||
   TT* (%) | 52.1 | 0.0 | 83.9 | 0.0 | 101.28 | <.001 |
   CC (%) | 5.6 | 56.0 | 3.6 | 59.5 | 39.60 | <.001 |
   TC (%) | 42.3 | 44.0 | 12.5 | 40.5 | 6.12 | <.001 |
CFH rs1061170 (Y402H) | ||||||
   TT (%) | 31.0 | 0.0 | 35.7 | 0.0 | 20.68 | <.001 |
   CC* (%) | 32.4 | 41.7 | 21.4 | 57.1 | 5.06 | .002 |
   CT (%) | 36.6 | 58.3 | 42.9 | 42.9 | 2.72 | .045 |