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Table 2 Allele and genotype distributions of MTNR1B polymorphisms in GDM and control subjects

From: Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus

Loci

Genotype

RAF

N (%)

Referent

Co-dominant

Dominant

Recessive

  

GDM

Controls

GDM

Controls

OR(95%CI)

Pcor.

OR(95%CI)

Pcor.

OR(95%CI)

Pcor.

OR(95%CI)

Pcor.

 

CC

  

235(25.9%)

313(32.2%)

1

       
 

CT

  

433(47.6%)

455(46.8%)

1.33

0.1

1.3

0.0008

1.44

0.008

1.42

0.03

rs1387153

 

0.503

0.444

  

(1.06-1.66)

 

(1.14-1.49)

 

(1.17-1.78)

 

(1.14-1.78)

 
 

TT

  

241(26.5%)

204(21.0%)

1.29

0.001

      
      

(1.13-1.47)

       
 

CC

  

217(23.9%)

294(30.4%)

1

       
 

CG

  

435(47.9%)

469(48.6%)

1.31

0.2

1.35

0.0001

1.46

0.006

1.54

0.001

rs10830963

 

0.521

0.453

  

(1.04-1.65)

 

(1.18-1.54)

 

(1.18-1.81)

 

(1.23-1.92)

 
 

GG

  

256(28.2%)

203(21.0%)

1.34

0.0001

      
      

(1.18-1.53)

       
  1. P values were corrected for multiple testing by multiplying the number of tests (10 tests, 2 SNPs × 5 tests (2 referent, co-dominant, dominant and recessive models)) (Bonferroni correction). RAF, risk allele frequency.
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BMC Medical Genetics

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