Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians

Suriapranata, Ivet M; Tjong, Wen Ye; Wang, Tingliang; Utama, Andi; Raharjo, Sunu B; Yuniadi, Yoga; Tai, Susan SW

doi:10.1186/1471-2350-12-80

BMC Medical Genetics

Table 2 Allele frequencies and genotype distribution of SNPs evaluated in this study

From: Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians

Gene	SNP	Position relative to transcription start site	Allele	n	%	MAF	Genotype	n	%	P-Value HWE
CYP2C9**	rs17847036	3259	G	265	98.15	0.9815	GG	130	96.30	0.8265
			A	5	1.85	0.0185	GA	5	3.70
							AA	0	0.00
	Novel SNP	3164	G	224	91.80	0.9180	GG	102	83.61	0.3240
	Intron 2		A	20	8.20	0.0820	GA	20	16.39
							AA	0	0.00
	rs9332120	3435	T	264	97.78	0.9778	TT	129	95.56	0.7917
			C	6	2.22	0.0222	TC	6	4.44
							CC	0	0.00
	rs2860905	3880	G	224	91.80	0.9180	GG	104	85.25	0.1556
			A	20	8.20	0.0820	GA	16	13.11
							AA	2	1.64
	rs28371675	3922	C	198	81.15	0.8115	CC	79	64.75	0.4291
			T	46	18.85	0.1885	CT	40	32.79
							TT	3	2.46
	rs28371676	3948	T	234	95.90	0.9590	TT	112	91.80	0.6369
			C	10	4.10	0.0410	TC	10	8.20
							CC	0	0.00
	rs28371677	4057	A	224	91.80	0.9180	AA	104	85.25	0.1556
			G	20	8.20	0.0820	AG	16	13.11
							GG	2	1.64
	rs9332127	9056	G	234	95.90	0.9590	GG	112	91.80	0.6369
	(CYP2C9C-65)		C	10	4.10	0.0410	GC	10	8.20
							CC	0	0.00
	rs9332129	10322	A	234	96.69	0.9630	AA	112	92.56	0.6696
			G	9	3.72	0.0370	AG	9	7.44
							GG	0	0.00
	rs1057910	42625	A	235	96.31	0.9631	AA	113	92.62	0.6723
	(CYP2C93*)		C	9	3.69	0.0369	AC	9	7.38
							CC	0	0.00
	Novel SNP	47635	C	240	98.36	0.9836	CC	118	96.72	0.8539
	Intron 8		T	4	1.64	0.0164	CT	4	3.28
							TT	0	0.00
	rs2298037	47650	C	199	81.56	0.8156	CC	79	64.75	0.1957
			T	45	18.44	0.1844	CT	41	33.61
							TT	2	1.64
	rs9332238	50064	G	233	95.49	0.9549	GG	111	90.98	0.6020
			A	11	4.51	0.0451	GA	11	9.02
							AA	0	0.00
	rs1934969	50067	A	173	70.90	0.7090	AA	60	49.18	0.5595
			T	71	29.10	0.2910	AT	53	43.44
							TT	9	7.38
	rs1057911	50309	A	234	95.90	0.9590	AA	112	91.80	0.6369
			T	10	4.10	0.0410	AT	10	8.20
							TT	0	0.00
VKORC1	rs9923231	-1639	A	208	77.04	0.7704	AA	78	57.78	0.3027
			G	62	22.96	0.2296	AG	52	38.52
							GG	5	3.70
EPHX1	rs4653436	-2586	G	203	87.50	0.8750	GG	91	78.45	0.0633
			A	29	12.50	0.1250	GA	21	18.10
							AA	4	3.45
GGCX	rs12714145	1291	C	145	59.43	0.5943	CC	34	27.87	0.0006
			T	99	40.57	0.4057	CT	77	63.11
							TT	11	9.02
PROC	rs2069920	3643	C	140	57.38	0.5738	CC	36	29.51	0.1232
			T	104	42.62	0.4262	CT	68	55.74
							TT	18	14.75
PROC	rs1799808	-141	C	99	40.57	0.4057	CC	15	12.30	0.0563
			T	145	59.43	0.5943	CT	69	56.56
							TT	38	31.15
PROC	rs1799809	-128	A	141	57.79	0.7747	AA	72	59.02	0.3009
			G	41	16.80	0.2253	AG	46	37.70
							GG	4	3.28
CYP4F2	rs2108622	18454	C	198	81.15	0.8115	CC	82	67.21	0.3248
			T	46	18.85	0.1885	CT	34	27.87
							TT	6	4.92

** SNPs in CYP2C9 with MAF ≤ 0.01: CYP2C9*2 (rs1799853); CYP2C9*4 (rs56165452); CYP2C9*5 (rs28371686); rs17847032; rs2017319; CYP2C9*6 (rs9332131); rs9332173; CYP2C9*7; CYP2C9*8 (rs7900194); rs5031019; CYP2C9*9 (rs2256871); CYP2C9*10 (rs9332130); CYP2C9*11 (rs28371685); rs1057909; CYP2C9*12 (rs9332239); rs9332100; CYP2C9*13; rs12414460

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ISSN: 1471-2350

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