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Table 2 Information of the polymorphisms included in the study

From: Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder

Name

Reference

SNP/F

Location

A1

A2

Forward Primers

Reverse Primers

Minisequencing Primers

Mult.

SHMT1

rs1979276

SNP

3'-UTR

A

G

CTGGCAGGGGATAAGTACCAG

GTCAACAGTTCCCCTTTGGA

CCGGAGGACCCCCAC

SNP1

 

rs1979277

SNP

EXON

A

G

CTGGCAGGGGATAAGTACCAG

GTCAACAGTTCCCCTTTGGA

(T)31-GCCAGGCAGAGGGAAGA

SNP1

 

rs643333

SNP

5'-UTR

A

C

TGGACGCACATTTGTCCTAC

ATCAGAGAGCGCAGCCAAG

(T)24-ACCTGCAGAACTGACCC

SNP1

 

rs638416

SNP

5'-UTR

C

G

TGGACGCACATTTGTCCTAC

ATCAGAGAGCGCAGCCAAG

(T)91-GCAGGGCCTGTTTCTCC

SNP1

 

rs3783

SNP

3'-UTR

C

G

CTGGCAGGGGATAAGTACCAG

GTCAACAGTTCCCCTTTGGA

(T)115-GGGGTCCTCCGGCAG

SNP1

TYMS

rs2853542

SNP

5'-UTR

C

G

GTGCCACACCCGTGGCTCC

GCCACAGGCATGGCGCGG

(T)84-GGGACGGAGGCAGGC

SNP1

 

rs34489327

F

3'-UTR

I

D

PET-CAAATCTGAGGGAGCTGAGT

CAGATAAGTGGCAGTACAGA

 

F

 

rs34743033

F

5'-UTR

2R

3R

VIC-GTGCCACACCCGTGGCTCC

GCCACAGGCATGGCGCGG

 

F

TCN

rs9606756

SNP

EXON

A

G

GGAGAAGGCCCTGGTAACG

CTTCCTTGGTCCCAGCCTG

(T)64-GGCTGTCCATCTCTGGTA

SNP1

 

rs1801198

SNP

EXON

C

G

GGGAAAGAGACCCTGGAGC

GCTGGGAAATCATGAGAGC

(T)58-CCCAGTTCTGCCCCA

SNP2

MTHFR

rs1801131

SNP

EXON

A

C

CTTTGGGGAGCTGAAGGACTACTAC

CACTTTGTGACCATTCCGGTTTG

(T)71-AGGAGCTGACCAGTGAAG

SNP2

 

rs1801133

SNP

EXON

C

T

GTGGTCTCTTCATCCCTCG

GACGGTGCGGTGAGAGTG

GAAGGTGTCTGCGGGAG

SNP2

CBS

rs5742905

SNP

EXON

C

T

GGTTCTTGGGTTTCTCATCC

CTCCGTCTGGTTCAGCTCC

(T)42-GCGCCCTCTGCAGATCA

SNP2

 

cbs844ins68

F

INTR/EXON

S

L

6FAM-GTTGTTAACGGCGGTATTGG

GTTGTCTGCTCCGTCTGGTT

 

F

ABCB1

rs1045642

SNP

EXON

C

T

GCTGAGAACATTGCCTATGG

TAAGGGTGTGATTTGGTTGC

(T)34-GGTGTCACAGGAAGAGAT

SNP2

ATIC

rs2372536

SNP

EXON

C

G

CCTAGATAGCTGTAAACCAC

GTAATCCCAAAACACAATC

(T)18-CCACAGCCTCCTCAACA

SNP1

BHMT

rs3733890

SNP

EXON

A

G

TGTGAACTGCCACTTTGACC

ATGGGAATTCTGGGAGATCG

ATCAGGTGAGCTTTCAGT

SNP1

DHFR

DHFR19bpdel

F

INTRON

+

-

ACGGTCGGGGTGGCCGACTC

6FAM-AAAAGGGGAATCCAGTCGG

F

GSTM1

GSTM1del

F

EXON

+

-

PET-GAACTCCCTGAAAAGCTAAAGC

GTTGGGCTCAAATATACGGTGG

F

MTHFD1

rs2236225

SNP

EXON

C

T

CCCACTTTGAAGCAGGATTG

CATCCCAATTCCCCTGATG

(T)59-AACAAGCTTGAGTGCGATC

SNP1

MTR

rs12749581

SNP

EXON

A

G

GCATTGACCATTACTACACC

TCCAAAGCCTTTTACACTCC

AATATGAAGATATTAGACAGG

SNP2

MTRR

rs1801394

SNP

EXON

A

G

TTTCAGTTTCACTGTTACATGC

GTAACGGCTCTAACCTTATCG

(T)51-ACCACAGCTTGCTCACA

SNP1

RFC1

rs1051266

SNP

EXON

A

G

TTCCAGGCACAGTGTCACC

CCGCGTGAAGTTCTTGTCG

(T)40-CCGGTCCTGGCGGC

SNP1

ESR1

rs9340799

SNP

INTRON

A

G

AGGGTTATGTGGCAATGACG

CTGCACCAGAATATGTTACC

(T)4-AGACCCTGAGTGTGGTCT

SNP2

 

rs2234693

SNP

INTRON

C

T

AGGGTTATGTGGCAATGACG

CTGCACCAGAATATGTTACC

(T)28-AGTTCCAAATGTCCCAGC

SNP2

DRD4

drd4-48bptr

F

EXON

S

L

NED-GCTGCTGCTCTACTGGGC

CCCGGCCGGTGATCTTGG

 

F

SLC6A4

SCL6A45-HTTLPR

F

5-HTTLPR

S

L

VIC-GCGTTGCCGCTCTGAAGTC

GTGCCACCTAGACGCCAGG

 

F

  1. SNP = Single Nucleotide Polimorphism; F = Fragment or Repeat; A1 = Allele 1; Allele2; MULT = Multiplex Reaction;SHMT1 = Serine Hydroxymethyltransferase1; TYMS = Thymidylate Synthetase; TCN = Transcobalamin II; MTHFR = 5,10-Methylenetetrahydrofolate Reductase; CBS = Cystathionine Beta-Synthase; ABCB1 = ATP-Binding Cassette B1; ATIC = 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase; BHMT = Betaine-Homocysteine Methyltransferase; DHFR = Dihydrofolate Reductase; MTHFD1 = Methylenetetrahydrofolate Dehydrogenase 1; MTR = 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; MTRR = Methionine Synthase Reductase; RFC1 = Reduced Folate Carrier 1; ESR1 = Estrogen Receptor 1; DRD4 = Dopamine Receptor D4; SLC6A4 = Solute Carrier Family 6
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BMC Medical Genetics

ISSN: 1471-2350

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