Table 5 Mean age at onset ± standard errors of sporadic CJD patients across molecular subtypes and PRNP 310C allele distribution
Molecular subtype | PRNP 310C carriers | N | PRNP 310C non carriers | N | Mean difference (Years) | p-value |
|---|---|---|---|---|---|---|
MM1 | 57.7 ± 8.1 | 2 | 67.9 ± 9.1 | 31 | -10.2 | 0.1 |
MM2 | - | - | 53.8 ± 6.9 | 4 | - | - |
MV1 | - | - | 78.1 | 1 | - | - |
MV2 | 64.8 | 1 | 66.2 ± 5.4 | 7 | -1.4 | 0.8 |
VV1 | 41.0 | 1 | 64.0 | 1 | -23 | - |
VV2 | 64.3 ± 10.5 | 4 | 64.8 ± 11.2 | 10 | -0.5 | 0.9 |
Overall means* | 56.9 ± 3.8 | 8 | 65.8 ± 2.4 | 54 | -8.9 | 0.05 |