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Table 4 Quantitative traits stratified according to GCKR genotypes in non-diabetic controls

From: Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study

  n BMI (kg/m2) Waist circumference (cm) Fasting glucose (mmol/l) Total cholesterol* (mmol/l) Triglyceride* (mmol/l) HDL-C* (mmol/l) LDL-C* (mmol/l) Systolic BP (mmHg) Diastolic BP (mmHg)
rs8179206           
AA 1076 23.50 ± 0.09 80.50 ± 0.29 4.86 ± 0.01 5.11 ± 0.03 1.45 ± 0.02 1.32 ± 0.01 3.01 ± 0.03 119.14 ± 0.46 77.95 ± 0.27
AG 68 23.33 ± 0.39 81.48 ± 1.23 4.86 ± 0.05 5.04 ± 0.11 1.52 ± 0.09 1.30 ± 0.03 2.95 ± 0.10 122.28 ± 1.99 79.55 ± 1.11
GG$ 2 19.47 ± / 68.00 ± / 4.10 ± / 3.80 ± / 0.90 ± / 1.16 ± / 2.23 ± / 110.00 ± / 70.00 ± /
P valuea#   0.36 0.33 0.19 0.27 0.51 0.61 0.53 0.45 0.76
P valueb#     0.15 0.31 0.49 0.24 0.64 0.35 0.72
rs2293572           
GG 842 23.53 ± 0.10 80.60 ± 0.32 4.85 ± 0.01 5.09 ± 0.03 1.44 ± 0.02 1.32 ± 0.01 3.00 ± 0.03 119.32 ± 0.53 78.13 ± 0.31
GC 276 23.37 ± 0.17 80.22 ± 0.58 4.87 ± 0.02 5.16 ± 0.06 1.51 ± 0.04 1.31 ± 0.02 3.03 ± 0.05 118.96 ± 0.90 77.54 ± 0.50
CC 23 24.03 ± 0.53 80.00 ± 1.85 4.98 ± 0.06 5.39 ± 0.19 1.53 ± 0.15 1.39 ± 0.06 3.12 ± 0.17 121.24 ± 1.95 78.96 ± 1.29
P valuea#   0.48 0.63 0.18 0.17 0.28 0.54 0.74 0.14 0.24
P valueb#     0.14 0.17 0.15 0.37 0.73 0.19 0.44
rs3817588           
AA 598 23.35 ± 0.12 79.88 ± 0.40 4.85 ± 0.02 5.13 ± 0.04 1.50 ± 0.03 1.32 ± 0.01 3.02 ± 0.04 119.27 ± 0.66 77.79 ± 0.38
AG 423 23.52 ± 0.15 81.14 ± 0.47 4.87 ± 0.02 5.08 ± 0.05 1.41 ± 0.03 1.33 ± 0.02 3.00 ± 0.04 118.93 ± 0.76 78.12 ± 0.45
GG 103 23.97 ± 0.30 82.13 ± 1.01 4.84 ± 0.04 4.99 ± 0.10 1.26 ± 0.05 1.32 ± 0.03 2.95 ± 0.08 119.58 ± 1.68 77.77 ± 0.94
P valuea#   0.15 0.04 0.84 0.35 0.001& 0.78 0.82 0.59 0.76
P valueb#     0.81 0.29 0.00004& 0.70 0.84 0.39 0.63
rs780094           
AA 368 23.22 ± 0.16 79.66 ± 0.50 4.84 ± 0.02 5.12 ± 0.05 1.49 ± 0.04 1.32 ± 0.02 3.02 ± 0.05 119.13 ± 0.87 77.83 ± 0.50
AG 558 23.59 ± 0.13 80.80 ± 0.42 4.86 ± 0.02 5.13 ± 0.04 1.44 ± 0.03 1.32 ± 0.01 3.02 ± 0.04 119.73 ± 0.70 78.40 ± 0.39
GG 218 23.67 ± 0.20 81.34 ± 0.70 4.85 ± 0.03 5.00 ± 0.07 1.35 ± 0.04 1.32 ± 0.02 2.92 ± 0.06 119.15 ± 1.04 77.33 ± 0.62
P valuea#   0.15 0.16 0.74 0.32 0.06 0.79 0.40 0.96 0.24
P valueb#     0.63 0.31 0.03 0.30 0.43 0.99 0.18
  1. Data are expressed as the means ± SEM
  2. a Adjusted for year of birth and sex
  3. b Adjusted for year of birth, sex and BMI
  4. * Variables were log-transformed before statistical analysis; numbers in the table were back-transformed
  5. # p for trend
  6. $ This group had too few subjects and no SEM was calculated
  7. &Significant after Bonferroni correction (p < 0.0014 (0.05/36) was the corrected statistically significant level in association analysis between the individual SNP and quantitative traits in the control group)