CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey

BMC Medical Genetics

Table 6 Adjusted and weighted association between CRP polymorphism rs2808630 and albuminuria in African Americans Participants.

Models	Genotype	OR	95% CI	¥ p-value
rs2808630
Adjusted for Age and gender (Model 1).	AA	ref*
	AG	1.68	1.27, 2.23	0.0009
	GG	0.99	0.47, 2.28	0.9
Adjusted for risk factors	AA	ref*
	AG	2.95	1.54, 5.67	0.002
	GG	1.78	0.50, 76.34	0.4
Adjusted for risk factors and Log transformed CRP (Model 2).	AA	ref*
	AG	3.07	1.59, 5.94	0.002
	GG	1.91	1.00, 6.54	0.3

*ref. reference group homozygous for the major allele.
¥ Unadjusted for multiple comparisons
* Statistical significance with Bonferroni correction (α/n = 0.05/29) p-value ≤ 0.002
Odd ratios are adjusted for:
Model 1:adjusted for age, sex and GFR.
Model 2:age, gender, diabetes, hypertension, cardiovascular disease, BMI, cotinine levels, NSAIDS exposure, LDL cholesterol, GFR and log transformed C reactive protein.

ISSN: 1471-2350