CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey

BMC Medical Genetics

Table 5 Association between CRP variants and eGFR-MDRD

	linear regression to eGFR (log transformed) for each SNP
	Non-Hispanic Whites		Non-Hispanic Blacks		Mexican Americans
	β(95% CI)	¥ p-value	β (95% CI)	¥ p-value	β(95% CI)	¥ p-value
rs2808630
Unadjusted	-0.001 (-0.02, 0.01)	0.55	-0.01 (-0.04,0.02)	0.61	-0.01 (-0.01, 0.03)	0.54
Fully adjusted	-0.01 (-0.04, 0.02)	0.46	0.00 (-0.04, 0.04)	0.94	0.01 (-0.01, 0.04)	0.20
rs1205
Unadjusted	-0.001 (-0.02, 0.01)	0.76	-0.01 (-0.03, 0.02)	0.53	-0.001(-0.01, 0.02)	0.55
Fully adjusted	-0.001 (-0.02, 0.02)	0.84	-0.01 (-0.04, 0.01)	0.32	0.01 (-0.02, 0.04)	0.55
rs1417938
Unadjusted	0.001 (-0.02, 0.02)	0.72	-0.01(-0.04, 0.02)	0.54	-0.01 (-0.03, 0.01)	0.51
Fully adjusted	0.01 (-0.01, 0.03)	0.35	-0.02 (-0.05, 0.01)	0.18	-0.001(-0.03, 0.03)	0.84
rs1800947
Unadjusted	-0.001 (-0.05, 0.04)	0.87	0.01 (-0.13, 0.16)	0.84	0.03 (- 0.02, 0.07)	0.26
Fully adjusted	0.01(-0.07, 0.09)	0.75	0.04 (-0.20, 0.27)	0.75	0.01 (-0.04, 0.06)	0.72
rs3093058
Unadjusted	-0.08 (-0.31, 0.14)	0.45	0.01 (-0.01, 0.04)	0.36	0.01 (-0.05, 0.06)	0.78
Fully adjusted	-0.04 (-0.13, 0.05)	0.36	-0.01 (-0.04, 0.02)	0.63	-0.03 (-0.11, 0.04)	0.34
rs3093066
Unadjusted	0.02 (-0.19, 0.23)	0.86	0.02 (-0.01, 0.04)	0.16	-0.03 (-0.09, 0.03)	0.37
Fully adjusted	0.06 (-0.13, 0.25)	0.53	0.01 (-0.02, 0.03)	0.68	-0.01 (-0.11, 0.08)	0.78

¥ Unadjusted for multiple comparisons
Fully adjusted: age, gender, diabetes, hypertension, cardiovascular disease, BMI, smoking, LDL cholesterol, log transformed C reactive protein and albuminuria

ISSN: 1471-2350