Skip to main content

Table 3 Genetic risk profile using CARD15/NOD 2, IL23R, PTGER4, and IRGM susceptibility alleles.

From: Evaluation of 22 genetic variants with Crohn's Disease risk in the Ashkenazi Jewish population: a case-control study

Risk profile

N (%)

OR (95% CI)

P

Sensitivity

Specificity

PPV

NPV

Accuracy

 

CD

Control

       

Number of risk alleles

≥3

366 (99)

489 (97)

3.49 (0.99-12.24)

0.05

99.2

2.8

42.8

82.4

43.6

≥4

354 (96)

425 (84)

4.33 (2.48-7.66)

5.80*10-8

95.9

15.5

45.4

83.9

49.5

≥5

316 (86)

310 (62)

3.71 (2.64-5.23)

3.95*10-15

85.6

38.4

50.5

78.5

58.4

≥6

214 (58)

152 (30)

3.19 (2.41-4.22)

1.94*10-16

57.9

69.8

58.5

69.4

64.5

≥7

107 (29)

39 (8)

4.86 (3.27-7.22)

9.88*10-17

29.0

92.2

73.3

63.9

65.5

≥8

27 (7)

3 (0.6)

13.16 (3.96-43.72)

4.29*10-8

7.3

99.4

90.0

59.4

60.4

Weighted Score

≥2

368 (>99)

498 (99)

3.69 (0.43-31.75)

0.25

99.7

1.0

42.5

83.3

42.8

≥3

361 (99)

470 (93)

3.17 (1.45-6.94)

0.003

97.8

6.6

43.4

80.5

45.2

≥4

331 (90)

377 (75)

2.91 (1.97-4.31)

4.13*10-8

89.7

25.0

46.8

76.8

52.4

≥5

287 (78)

259 (51)

3.30 (2.44-4.46)

2.42*10-15

77.8

48.5

52.6

74.8

60.9

≥6

216 (59)

138 (27)

3.73 (2.81-4.97)

1.97*10-20

58.5

72.6

61.0

70.5

66.6

≥7

174 (47)

88 (17)

4.21 (3.09-5.72)

3.65*10-21

47.2

82.5

66.4

68.0

67.5

≥8

124 (34)

42 (8)

5.56 (3.79-8.15)

5.14*10-21

33.6

91.7

74.7

65.3

67.1

≥9

108 (29)

27 (5)

7.69 (4.89-12.11)

3.49*10-23

29.3

94.6

80.0

64.6

67.0

≥10

73 (20)

20 (4)

9.45 (5.15-17.34)

5.74*10-18

19.8

96.0

78.5

62.0

63.8

≥11

53 (14)

13 (3)

14.2 (6.04-33.40)

1.76*10-15

14.4

97.4

80.3

60.8

62.3

  1. OR (95% CI), Odds ratio (95% confidence interval); PPV, Positive predictive value; NPV, Negative predictive value.