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Table 1 Univariate Analysis of Susceptibility Loci with Crohn's Disease Status.

From: Evaluation of 22 genetic variants with Crohn's Disease risk in the Ashkenazi Jewish population: a case-control study

Gene

SNP ID

Amino acid substitution

Allele frequency

OR(95% CI)1

P-value

   

Controls (n = 503)

Cases (n = 369)

  

NOD2

rs2066844

p.R702W

0.02

0.04

1.85 (1.08-3.18)

0.03

 

rs2066845

p.G908R

0.04

0.11

3.23 (2.15-4.85)

6.39*10-9

 

rs2066847

p.L1007fs2

0.02

0.11

5.18 (3.26-8.25)

2.03*10-12

 

Carriage3

 

0.14

0.34

4.13(3.00-5.67)

1.49*10-19

 

Compound Hetero/Homozygous4

 

0.01

0.09

8.68 (3.61-20.87)

1.10*10-8

 

rs17221417

intron 2

0.22

0.38

2.13 (1.73-2.63)

1.32*10-12

 

rs2076756

intron 8

0.22

0.39

2.26 (1.83-2.79)

6.50*10-14

IL23R

rs11209026

R381Q

0.07

0.02

0.27 (0.16-0.48)

4.73*10-6

 

rs7517847

intron 6

0.38

0.25

0.55 (0.43-0.68)

6.88*10-8

 

rs11805303

intron 6

0.35

0.41

1.32 (1.09-1.61)

0.0076

IRGM

rs13361189

intergenic

0.16

0.21

1.47 (1.15-1.88)

0.0014

 

rs11747270

intergenic

0.15

0.21

1.48 (1.16-1.90)

0.0012

 

rs1000113

intergenic

0.15

0.21

1.49 (1.17-1.91)

0.0011

PTGER4

rs1373692

p.T300A

0.61

0.67

1.29 (1.06-1.58)

0.012

 

rs1992660

intergenic, near 5'-UTR

0.60

0.65

1.21 (0.99-1.47)

0.062

 

rs4613763

intergenic

0.07

0.08

1.05 (0.74-1.51)

0.77

ATG16L1

rs2241880

intergenic

0.59

0.63

1.18 (0.97-1.43)

0.10

 

rs10210302

intergenic

0.59

0.62

1.14 (0.94-1.39)

0.19

NKX2-3

rs11190140

intergenic, near 5'-UTR

0.45

0.43

0.92 (0.76-1.11)

0.36

IL12B

rs6887695

intergenic

0.32

0.32

1.03 (0.84-1.26)

0.81

 

rs10045431

intergenic

0.71

0.69

0.94 (0.77-1.16)

0.59

PTPN2

rs2542151

intergenic

0.10

0.12

1.20 (0.89-1.63)

0.22

TNFSF15

rs4263839

intron 1

0.76

0.75

0.95 (0.77-1.19)

0.67

STAT3

rs744166

intron 1

0.61

0.62

0.99 (0.82-1.21)

0.93

  1. OR (95% CI), Odds ratio (95% confidence interval); 1 Test for allelic trend; 2 fs, Frame shift; 3 Carriage of at least one of the above three NOD2/CARD15 risk alleles, and 4 Homozygous carriage of at least one of the above risk alleles or heterozygous carriage of more than one of the above risk alleles.