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Table 2 KRT8 diplotype distributions

From: An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion

KRT8 diplotype rs1907671-rs4300473-rs2035878-rs2035875 E CON- CON+ ICM no Res. ICM CFTR Res.
1122/1122 0.183 0.141 0.047 0.570 0.045
1122/2211 0.405 0.588 0.439 0.357 0.589
2211/2211 0.224 0.101 0.428 0.071 0.182
other pooled 0.188 0.170 0.086 0.002 0.184
P   Praw = 0.0319; Pcorr = 0.0252 Praw = 0.0049; Pcorr = 0.0035
  1. Alleles at all PCR-RFLP typed SNPs are named for absence (allele 1) or presence (allele 2) of diagnostic restriction site; E: expectancy values, based on Hardy-Weinberg-Law, relying on haplotype frequencies given in Table 1 for entire cohort (101 CF families); CON+: concordant mildly affected patient pair (13 families) [5]; CON-: concordant severely affected patient pair (12 families) [5]; ICM Res.: patients who exhibit CFTR-mediated residual chloride secretion in ICM (intestinal current measurement; 22 families) [5]; ICM no Res.: patients who do not exhibit residual chloride secretion in ICM (intestinal current measurement; 14 families) [5]; Praw: observed uncorrected P-value; Pcorr: corrected for multiple testing of 4 SNPs [25]