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Table 1 KRT8 haplotype distributions

From: An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion

KRT8 haplotype rs1907671-rs4300473-rs2035878-rs2035875 T CON- CON+ ICM no Res. ICM CFTR Res.
1122 0.428 0.515 0.287 0.731 0.394
2211 0.473 0.399 0.670 0.269 0.526
other pooled 0.099 0.086 0.043 < 0.001 0.080
P   Praw = 0.0028; Pcorr = 0.0051 Praw = 0.0151; Pcorr = 0.0049
  1. Alleles at all PCR-RFLP typed SNPs are named for absence (allele 1) or presence (allele 2) of diagnostic restriction site [5]; T: transmitted chromosomes of the entire patient population of 101 CF families (171 F508del-CFTR homozygotes) [5]; CON+: concordant mildly affected patient pair (13 families) [5]; CON-: concordant severely affected patient pair (12 families) [5]; ICM Res.: patients who exhibit CFTR-mediated residual chloride secretion in ICM (intestinal current measurement; 22 families) [5]; ICM no Res.: patients who do not exhibit residual chloride secretion in ICM (intestinal current measurement; 14 families) [5]; Praw: observed uncorrected P-value; Pcorr: corrected for multiple testing of 4 SNPs [25]