Evidence of association with type 1 diabetes in the SLC11A1 gene region

BMC Medical Genetics

Table 2 Summary of T1D association results for the family collections

Variant	Number of families	Number of informative transmissions	Minor allele frequency (%) in affected siblings	Minor allele frequency (%) in unaffected parents	Relative risk (95% C.I.)	Family P _TDT
rs4674297 G>A	NA	NA	NA	NA	NA	NA
Microsatellite (GT)n 3*>2	1971	1925	27.02	27.06	1.00 (0.92-1.10)	0.87
rs7573065 C>T	2472	610	5.43	5.30	0.92 (0.78-1.08)	0.29
rs2276631 C>T	2707	2587	27.38	27.15	1.00 (0.93-1.08)	0.98
rs3731865 G>C	5010	4876	26.43	26.42	1.00 (0.95-1.06)	0.98
rs2279015 G>A	2523	2862	36.33	36.26	0.94 (0.88-1.02)	0.13
rs17235409 G>A	1859	198	2.05	2.10	0.92 (0.70-1.22)	0.57
rs17235416 TGTG>del	2450	191	1.61	1.65	0.85 (0.64-1.14)	0.28
rs1059823 A>G	2591	2950	39.79	38.81	1.02 (0.95-1.10)	0.56
rs1809231 C>G	2678	3166	42.71	42.14	1.01 (0.94-1.08)	0.78

Number of families with genotyping data for the variants in the SLC11A1 gene region with the respective number of informative transmissions, the relative risk and the P-value from the transmission/disequilibrium test (P _TDT). [* Rare microsatellite alleles, with frequency <0.1%, were combined with the common allele 3; 95% C.I. = 95% confidence interval; NA = not available]

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