Evaluation of variants in the selectin genes in age-related macular degeneration

Mullins, Robert F; Skeie, Jessica M; Folk, James C; Solivan-Timpe, Frances M; Oetting, Thomas A; Huang, Jian; Wang, Kai; Stone, Edwin M; Fingert, John H

doi:10.1186/1471-2350-12-58

BMC Medical Genetics

Table 2 Sub-group analysis of SNPs in SELE, SELL and SELP.

From: Evaluation of variants in the selectin genes in age-related macular degeneration

Gene	rs ID	Affect on encoded protein	Dry AMD vs. Normals Fisher's extact test		GA vs. Normals Fisher's extact test		Wet AMD vs. Normals Fisher's extact test
			Allele Frequency p-value	Genotype Frequency p-value	Allele Frequency p-value	Genotype Frequency p-value	Allele Frequency p-value	Genotype Frequency p-value
SELE	rs4786	-	0.38	0.54	0.087	0.21	0.44	0.56
SELE	rs3917438	-	0.75	0.73	0.43	0.70	0.028	0.039
SELE	rs5368	His468Tyr	0.81	0.35	0.42	0.20	0.52	0.75
SELE	rs2076059	-	0.65	0.62	0.46	0.67	0.42	0.28
SELE	rs3917454	-	>0.99	>0.99	0.74	0.73	>0.99	0.29
SELE	rs5361	Ser149Arg	0.91	0.61	0.35	0.45	0.47	0.71
SELE	rs12408179	-	0.68	0.92	0.74	0.71	0.36	0.13
SELL	rs909628	-	>0.99	0.93	0.12	0.35	0.34	0.65
SELL	rs2298902	-	0.34	0.12	0.70	>0.99	0.30	0.53
SELL	rs2223286	-	0.88	0.71	0.90	0.97	0.44	0.43
SELL	rs4987351	-	0.61	0.30	0.10	0.28	>0.99	0.37
SELL	rs2298900	-	0.88	0.73	0.036	0.096	0.21	0.28
SELL	rs2298899	-	0.31	0.45	0.19	0.25	0.42	0.32
SELL	rs4987318	-	0.30	0.54	0.045	0.13	0.49	0.60
SELP	rs3917843	-	0.22	0.21	0.762	0.76	0.74	0.20
SELP	rs17522707	-	0.62	0.72	0.42	0.92	0.83	0.26
SELP	rs6136	Thr756Pro	0.030	0.090	0.71	0.67	0.61	0.15
SELP	rs1569471	-	0.66	0.50	0.77	0.60	0.53	0.14
SELP	rs6133	Val640Leu	0.91	0.45	>0.99	0.63	0.49	0.62
SELP	rs6127	Asp603Asn	0.023	0.041	0.24	0.50	0.84	0.94
SELP	rs3917751	-	0.0029*	0.0066	0.093	0.012	0.31	0.14
SELP	rs3917740	-	0.65	0.52	0.19	0.31	0.69	0.90
SELP	rs3917739	-	0.48	0.45	0.54	0.55	0.20	0.31
SELP	rs2235304	-	0.88	0.88	0.078	0.069	0.28	0.26
SELP	rs3917734	-	0.94	0.99	0.70	0.91	0.39	0.65
SELP	rs6131	Ser331Asn	0.56	0.35	0.75	0.54	0.79	0.94
SELP	rs6125	Val209Met	>0.99	>0.99	0.59	0.58	0.77	0.76
SELP	rs3917686	-	0.30	0.39	0.36	0.28	0.76	0.81
SELP	rs3917682	-	0.56	0.81	0.23	0.10	0.60	0.36
SELP	rs3917681	-	0.57	0.72	0.25	0.092	0.76	0.91

Reported p-values are uncorrected for multiple measures and those uncorrected p-values < 0.05 are indicated by bold text. One SNPs in SELP (rs3917751) that is indicated by bold text and an asterisk produced a p-value below the corrected threshold of 0.0042.

Back to article page

ISSN: 1471-2350

Contact us

General enquiries: ORSupport@springernature.com