Skip to main content

Table 3 Diseases and functions reported to be associated with genes exhibiting a significant correlation between methylation and maternal age.

From: Parental ages and levels of DNA methylation in the newborn are correlated

Gene

Phenotype/Function

OMIM Reference

KCNQ1

Long QT Syndrome 1; Jervell and Lange-Nielsen Syndrome 1; Atrial fibrillation, familial 3; short QT Syndrome

192500 220400 607554 609621

TUBB2A

Polymicrogyria, asymmetric

610031

RAD51

Breast cancer, familial

114480

C19orf6

Ovarian, breast, pancreatic and colorectal cancer expression

611011

RAD54L

Adenocarcinoma, colonic, somatic; Lymphoma, non-Hodgkin; Breast cancer, invasive ductal

603615

ACADS

SCAD deficiency

201470

GM2A

Gangliosidase, AB variant

272750

STAT5B

Growth hormone insensitivity with immunodeficiency

245590

RET

Multiple endocrine neoplasia, type IIA; Hirschprung disease; Central hypoventilation syndrome; renal agenesis

142623 209880 191830

ZFYVE26

Spastic paraplegia 15, autosomal recessive

270700

RBBP9

Transformation to cancer

602908

MRPS22

Combined oxidative phosphorylation deficiency 5

611719

MYC

Burkitt lymphoma

113970

RFXDC1

Diabetes, neonatal, with pancreatic hypoplasia, intestinal atresia and gallbladder aplasia or hypoplasia

601346

MYST1

Histone acetyltransferase

609912

RASSF1

Tumor suppressor

605082

ZBT16

Skeletal defects, genital hypoplasia, and mental retardation

612447

ACTN4

Focal glomerulosclerosis 1

603278

NR0B2

Obesity, mild, early-onset

604630

ALX4

Parietal foramina 2

609597