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Figure 1 | BMC Medical Genetics

Figure 1

From: Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease

Figure 1

Simulated effects of genotype-differences in fatalities on the odds ratio for CVD in KIF6 719Arg carriers vs. noncarriers. KIF6 719Arg carriers are assumed to represent 59% of the population and to increase CVD risk by 50% (consistent with WOSCOPS and CARE trials [6]) and by 25% (consistent with ARIC and WHS [11, 13]) relative to noncarriers. X-axis represents the percent difference in fatality between carriers and noncarriers of the KIF6 allele (see methods).

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BMC Medical Genetics

ISSN: 1471-2350

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