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Table 2 The relationship between IA and proinsulin.

From: The PTPN22C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes

 

Doubling the level of IA

 

1 mth

6 mths

12 mths

Proinsulin

7%

11%

16%

 

P = 0.002

P = 0.007

P < 0.00001

  1. IA levels were associated with proinsulin independent of PTPN22 genotypes as a 100% increase of the IA corresponded to a significant increase in proinsulin release the first 12 months after disease onset.