Table 2 Genotype frequencies in RA patients and controls
SNP | Genotype frequency | p trenda | SNP | Genotype frequency | p trenda | ||
|---|---|---|---|---|---|---|---|
| Â | Controls n (%) | RA patients n (%) | Â | Â | Controls n (%) | RA patients n (%) | Â |
IL6-174 | Â | Â | Â | NOS2a 608 | Â | Â | Â |
C/C | 82 (17.9) | 56 (16.7) | 0.01 | G/G | 301 (65.2) | 254 (68.6) | 0.22 |
C/G | 231 (50.3) | 133 (39.7) | Â | G/A | 140 (30.3) | 104 (28.1) | Â |
G/G | 146 (31.8) | 146 (43.6) | Â | A/A | 21 (4.5) | 12 (3.2) | Â |
IL8 781 | Â | Â | Â | PARP 762 | Â | Â | Â |
C/C | 152 (32.9) | 141 (37.5) | 0.4 | T/T | 299 (66.6) | 261 (70.7) | 0.40 |
C/T | 234 (50.6) | 171 (45.5) | Â | T/C | 140 (31.2) | 96 (26.0) | Â |
T/T | 76 (16.5) | 64 (17.0) | Â | C/C | 10 (2.2) | 12 (3.3) | Â |
PAI1 4/5G | Â | Â | Â | IL4-524 | Â | Â | Â |
5G/5G | 99 (21.4) | 101 (27.7) | 0.12 | C/C | 339 (73.7) | 267 (71.8) | 0.30 |
5G/4G | 240 (51.9) | 172 (47.1) | Â | C/T | 112 (24.3) | 91 (24.5) | Â |
4G/4G | 123 (26.6) | 92 (25.2) | Â | T/T | 9 (2.0) | 14 (3.8) | Â |
TNFA-863 | Â | Â | Â | C1INH 480 | Â | Â | Â |
C/C | 329 (71.4) | 239 (64.8) | 0.16 | G/G | 255 (55.4) | 211 (58.3) | 0.47 |
C/A | 117 (25.4) | 123 (33.3) | Â | G/A | 176 (38.3) | 129 (35.6) | Â |
A/A | 15 (3.3) | 7 (1.9) | Â | A/A | 29 (6.3) | 22 (6.1) | Â |
TNFA-857 | Â | Â | Â | Il10-1082 | Â | Â | Â |
C/C | 386 (84.5) | 314 (86.5) | 0.29 | G/G | 123 (26.8) | 88 (24.7) | 0.77 |
C/T | 66 (14.4) | 48 (13.2) | Â | G/A | 219 (47.7) | 172 (48.3) | Â |
T/T | 5 (1.1) | 1 (0.3) | Â | A/A | 117 (25.5) | 96 (27) | Â |
TNFA-376 | Â | Â | Â | IL10-819 | Â | Â | Â |
G/G | 446 (96.7) | 371 (98.9) | 0.04 | C/C | 283 (61.5) | 233 (63.7) | 0.99 |
G/A | 15 (3.3) | 4 (1.1) | Â | C/T | 145 (31.5) | 100 (27.3) | Â |
A/A | Â | Â | Â | T/T | 32 (7.0) | 33 (9.0) | Â |
TNFA-308 | Â | Â | Â | TLR4 299 | Â | Â | Â |
G/G | 300 (65.1) | 248 (66.1) | 0.60 | A/A | 373 (86.3) | 315 (85.1) | 0.62 |
G/A | 147 (31.9) | 119 (31.7) | Â | A/G | 58 (13.4) | 54 (14.6) | Â |
A/A | 14 (3.0) | 8 (2.1) | Â | G/G | 1 (0.2) | 1 (0.3) | Â |
TNFA-238 | Â | Â | Â | TLR4 399 | Â | Â | Â |
G/G | 415 (90.0) | 359 (95.7) | 0.002 | C/C | 378 (87.1) | 314 (84.9) | 0.42 |
G/A | 46 (10.0) | 16 (4.3) | Â | C/T | 54 (12.4) | 55 (14.9) | Â |
A/A | Â | Â | Â | T/T | 2 (0.5) | 1 (0.3) | Â |
IL1B-31 | Â | Â | Â | Â | Â | Â | Â |
C/C | 57 (12.5) | 48 (12.8) | 0.62 | Â | Â | Â | Â |
C/T | 214 (46.9) | 165 (44.0) | Â | Â | Â | Â | Â |
T/T | 185 (40.6) | 162 (43.2) | Â | Â | Â | Â | Â |