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Table 5 Odds ratios and 95% confidence intervals for additive genetic model of MTHFR polymorphism by MTR genotypes, folate and homocysteine with risk of hearing impairment analyzed by a multiple logistic regression in a subgroup analysis.

From: Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study

 

No.

ORs (95% confidence interval)

MTR

Hearing impairment

No hearing impairment

MTHFR/T-allele

folate

homocysteine

AA

126

626

0.602 *

0.946

1.066 *

   

(0.421-0.861)

(0.861-1.039)

(1.021-1.113)

AG

71

281

1.379

0.941

0.953

   

(0.830-2.292)

(0.816-1.084)

(0.893-1.017)

GG

7

35

Data not shown (the validity of the model fit is questionable due to small number).

  1. N = 1146
  2. Asterisk shows statistically significance (p < 0.05). Parenthetical reference shows 95% confidence interval.
  3. [Moderator variable]
  4. age, sex, smoking status, BMI
  5. histories of occupational noise exposure, heart disease, hypertension, and diabetes
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BMC Medical Genetics

ISSN: 1471-2350

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