Table 2 Characteristics of subjects according to SLC22A12 W258X genotype
Characteristics | Males | Females | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | WW | WX | XX | P | WW | WX | XX | p |
| Â | n = 3,256 | n = 155 | n = 2 | Â | n = 1,537 | n = 70 | n = 3 | Â |
Age (years) | 50.6 | 52.0 | 52.5 | 0.166 | 49.1 | 51.4 | 58.3 | 0.017 |
Body mass index (kg/m2) | 23.5 | 23.7 | 20.9 | 0.240 | 22.0 | 21.9 | 19.7 | 0.407 |
Systolic blood pressure (mmHg) | 121.0 | 120.5 | 105.0 | 0.319 | 114.4 | 115.1 | 119.3 | 0.811 |
Diastolic blood pressure (mmHg) | 76.3 | 76.0 | 66.0 | 0.350 | 69.9 | 70.4 | 66.7 | 0.798 |
Total cholesterol (mg/dL) | 202.3 | 202.7 | 195.5 | 0.944 | 207.2 | 208.9 | 197.3 | 0.793 |
HDL cholesterol (mg/dL) | 57.7 | 56.0 | 63.5 | 0.338 | 71.1 | 69.7 | 88.3 | 0.159 |
Triglyceride (mg/dL) | 124.7 | 129.0 | 66.0 | 0.460 | 85.1 | 85.2 | 73.3 | 0.895 |
AST (U/dL) | 22.4 | 22.4 | 18.0 | 0.890 | 19.5 | 20.5 | 27.0 | 0.071 |
ALT (U/L) | 25.5 | 26.6 | 18.5 | 0.732 | 17.1 | 19.5 | 24.7 | 0.066 |
GGT (U/L) | 47.0 | 45.9 | 24.5 | 0.817 | 23.2 | 25.0 | 56.3 | 0.023 |
Creatinine (mg/dL) | 0.86 | 0.82 | 0.90 | 0.001* | 0.61 | 0.62 | 0.63 | 0.750 |
Blood urea nitrogen (mg/dL) | 14.3 | 14.5 | 16.0 | 0.567 | 13.1 | 14.0 | 15.0 | 0.057 |
Blood glucose (mg/dL) | 101.9 | 107.0 | 90.5 | 0.003* | 93.7 | 95.2 | 89.7 | 0.434 |