Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population

BMC Medical Genetics

Table 3 Association between haplotypes and asthma

Gene	Chr	BP1	BP2	SNP1	SNP2	Haplotype	Frequency	Odds Ratio	Unadjusted p	FDR
GSTM1	1	108482748	110031479	rs17672	rs3815029	CCG	0.10	3.01	0.05	0.210
	1	108482748	110031479	rs17672	rs3815029	CGC	0.11	0.36	0.04	0.209
	1	108482748	110031479	rs17672	rs3815029	CGG	0.64	0.82	0.506	0.781
	1	108482748	110031479	rs17672	rs3815029	TCC	0.01	4.48	0.298	0.626
	1	108482748	110031479	rs17672	rs3815029	TGC	0.05	1.58	0.508	0.781
	1	108482748	110031479	rs17672	rs3815029	TGG	0.09	1.18	0.759	0.839
	11	59612059	59622751	rs574700	rs502419	CCACG	0.08	1.63	0.286	0.626
	11	59612059	59622751	rs574700	rs502419	CCTAA	0.07	0.86	0.758	0.839
	11	59612059	59622751	rs574700	rs502419	CCTCA	0.01	1.02	0.982	0.982
MS4A2	11	59612059	59622751	rs574700	rs502419	CCTCG	0.07	0.78	0.595	0.781
	11	59612059	59622751	rs574700	rs502419	CTACG	0.57	1.58	0.114	0.399
	11	59612059	59622751	rs574700	rs502419	TCTAA	0.14	0.43	0.032	0.209
	11	59612059	59622751	rs574700	rs502419	TCTAG	0.04	1.04	0.96	0.982
	11	67106475	67110982	rs6591256	rs947895	AGACC	0.27	1.2	0.519	0.781
	11	67106475	67110982	rs6591256	rs947895	AGATA	0.07	0.28	0.027	0.209
	11	67106475	67110982	rs6591256	rs947895	AGATC	0.01	0.56	0.642	0.793
GSTP1	11	67106475	67110982	rs6591256	rs947895	AGGCC	0.21	2.23	0.018	0.209
	11	67106475	67110982	rs6591256	rs947895	GTACC	0.18	0.82	0.573	0.781
	11	67106475	67110982	rs6591256	rs947895	GTATA	0.02	0.19	0.201	0.603
	11	67106475	67110982	rs6591256	rs947895	GTGCC	0.03	1.59	0.562	0.781
	11	67106475	67110982	rs6591256	rs947895	GTGTA	0.19	0.70	0.288	0.626

† Logistic regression adjusted for sex and performed in PLINK version 1.06. SNP1: SNP of left-most (5') SNP in haplotype, SNP2: SNP of right most (3') SNP in haplotype. ß: Beta estimate, p: p-value. Statistical significance after correction for multiple comparisons evaluated using False Discovery Rate (FDR). FDR ≤ 0.25 denoted statistically significant associations, marked in bold. Models included 129 individuals.

ISSN: 1471-2350