Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population

BMC Medical Genetics

Table 2 Association between SNPs and asthma

Gene	Chr	Position	SNP	MAF	Odds Ratio (95% CI)	Unadjusted p	FDR
GSTM1	1	108482748	rs17672 C/T	0.16	1.47 (0.71, 3.04)	0.302	0.673
	1	110031467	rs412543 G/C	0.12	2.89 (1.14, 7.32)	0.025	0.207
	1	110031479	rs3815029 G/C	0.17	0.69 (0.33, 1.42)	0.312	0.673
MS4A2	11	59612059	rs574700 C/T	0.18	0.50 (0.23, 1.07)	0.042	0.249
	11	59612604	rs1441586 T/C	0.43	0.56 (0.25, 1.25)	0.114	0.390
	11	59615288	rs556917 A/T	0.34	0.47 (0.22, 0.97)	0.028	0.207
	11	59616754	rs502581 C/A	0.26	0.50 (0.24, 1.02)	0.030	0.207
	11	59622751	rs502419 G/A	0.24	0.45 (0.21, 0.93)	0.028	0.207
GSTP1	11	67106475	rs6591256 A/G	0.43	0.66 (0.31, 1.38)	0.162	0.495
	11	67107508	rs17593068 G/T	0.43	0.71 (0.34, 1.50)	0.169	0.495
	11	67109265	rs1695 A/G	0.44	1.61 (0.75, 3.42)	0.208	0.569
	11	67110420	rs1871042 C/T	0.30	0.44 (0.22, 0.91)	0.010	0.207
	11	67110982	rs947895 C/A	0.29	0.44 (0.22, 0.91)	0.015	0.207

† 41 SNPs evaluated as well as the GSTT1 deletion. Logistic regression adjusted for sex and performed in PLINK version 1.06. SNP major allele/minor allele noted, in that order. MAF: Minor allele frequency; Chr: Chromosome, 95% CI: 95% Confidence Intervals of the odds ratio, p: p-value. Statistical significance after correction for multiple comparisons evaluated using False Discovery Rate (FDR). FDR ≤ 0.25 denoted statistically significant associations, marked in bold. Data presented for genes with one or more statistically significant associations. Models included 129 individuals.

ISSN: 1471-2350