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Table 5 IREB2 Genotype frequencies and odds ratios in Controls and Cases.

From: The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study

SNP

No

Locus

Genotypes

Controls

COPD all

Cases

P-value

Odds Ratio+

     

Unadjusted

Adjusted*

Unadjusted

Adjusted **

(95% C.I.)

1

rs2568494

GG

42.2

35.0

0.0004

0.0018

1

1

 
  

GA

46.4

48.4

  

1.26

1.24

(1.00, 1.55)

  

AA

11.4

16.6

  

1.77

1.77

(1.29, 2.44)

2

rs2656069

AA

63.1

69.3

0.0006

0.0039

1

1

 
  

AG

32.2

28.7

  

0.81

0.85

(0.68, 1.06)

  

GG

4.8

2.0

  

0.37

0.37

(0.20, 0.69)

4

rs12593229

GG

36.9

45.6

0.0001

0.0053

1

1

 
  

GT

48.0

43.9

  

0.74

0.79

(0.63, 0.98)

  

TT

15.1

10.5

  

0.56

0.61

(0.44, 0.84)

  1. * p-values adjusted by logistic regression for age, sex, smoking and centre.
  2. + Odds ratios are relative to the major homozygous Genotype.
  3. ** Adjusted by logistic regression for age, sex, smoking and centre.
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BMC Medical Genetics

ISSN: 1471-2350

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