Skip to main content

Table 4 TGFÎ’1 and IREB2 Allele frequencies and odds ratios in Controls and Cases

From: The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study

Gene

SNP

No.

Locus

Major/

Minor

Alleles

Minor

Allele Frequencies

Unadjusted

P-value

Adjusted

P-value*

Adjusted

Odds Ratio**

(95% C. I.)

    

Controls

COPD

(all

cases)

   

TGFB1

2

rs1800469

C/T

0.32

0.32

0.8852

0.8314

1.02 (0.87, 1.18)

 

3

rs1800470

T/C

0.40

0.40

0.9118

0.8901

0.99 (0.86, 1.15)

 

4

rs6957

A/G

0.18

0.17

0.2736

0.2590

0.90 (0.74, 1.08)

IREB2

1

rs2568494

G/A

0.35

0.41

<0.0001

0.0005

1.30 (1.12, 1.50)

 

2

rs2656069

A/G

0.21

0.16

0.0004

0.0045

0.77 (0.64, 0.92)

 

4

rs12593229

G/T

0.39

0.32

<0.0001

0.0013

0.79 (0.68, 0.91)

  1. * p-values adjusted by logistic regression for age, sex, smoking and centre.
  2. ** Adjusted odds ratios are relative to the major Allele, adjusted by logistic regression for age, sex, smoking and centre.