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Table 2 Results of allelic imbalance analysis in low-penetrance CRC loci

From: Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci

Locus SNP Risk allele Neutral allele Imbalance a Loss neutral Loss risk P b
15q13 rs4779584 T C 17/87 (20%) 8 9 1
10p14 rs10795668 G A 12/90 (13%) 6 6 1
11q23 rs3802842 C A 9/89 (10%) 4 5 1
14q22 rs4444235 C T 17/90 (19%) 7 10 0.63
16q22 rs9929218 G A 10/90 (11%) 6 4 0.75
19q13 rs10411210 C T 15/174 (9%) 10c 5c 0.30
20p12 rs961253 A C 27/88 (31%) 11 16 0.44
  1. a Overall allelic imbalance per heterozygote tumour-normal pairs analyzed
  2. b Random targeting of alleles (exact binomial test)
  3. c Dukes A-B/C-D: Loss neutral 7/3, loss risk 2/3