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Table 2 Results of allelic imbalance analysis in low-penetrance CRC loci

From: Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci

Locus

SNP

Risk allele

Neutral allele

Imbalance a

Loss neutral

Loss risk

P b

15q13

rs4779584

T

C

17/87 (20%)

8

9

1

10p14

rs10795668

G

A

12/90 (13%)

6

6

1

11q23

rs3802842

C

A

9/89 (10%)

4

5

1

14q22

rs4444235

C

T

17/90 (19%)

7

10

0.63

16q22

rs9929218

G

A

10/90 (11%)

6

4

0.75

19q13

rs10411210

C

T

15/174 (9%)

10c

5c

0.30

20p12

rs961253

A

C

27/88 (31%)

11

16

0.44

  1. a Overall allelic imbalance per heterozygote tumour-normal pairs analyzed
  2. b Random targeting of alleles (exact binomial test)
  3. c Dukes A-B/C-D: Loss neutral 7/3, loss risk 2/3
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BMC Medical Genetics

ISSN: 1471-2350

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