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Table 3 Multiple regression analysis showing association between SNPs in KCNQ 1 and obesity and diabetes-related metabolic traits among non-diabetic controls

From: Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US

Punjabi Cohort (n = 1,048)

rs231362

rs2237892

rs2237895

   
 

Trait Mean

β (95%CI)

p adjustedΨ

β (95%CI)

p adjusted

β (95%CI)

p adjusted

   

BMI (kg/m2)

26.26 (25.94 - 26.58)

0.01 (-0.59 - 0.71)

0.860

-0.05 (-3.03 - 0.46)

0.150

0.04 (-0.23 - 1.13)

0.192

   

WHR

0.94 (0.93 - 0.94)

-0.02 (-0.04 - -0.01)

0.010

0.00 (-0.03 - 0.03)

0.992

-0.01 (-0.02 - 0.00)

0.149

   

FBG (mg/dL)

95.18 (94.30 - 96.05)

-0.04 (-0.02 - 0.01)

0.220

-0.06 (-0.08 - 0.01)

0.088

-0.01 (-0.03 - 0.01)

0.310

   

INSULIN (IU/mL)

7.35 (6.82 - 7.92)

0.06 (-0.03 - 0.28)

0.107

0.03 (-0.25 - 0.52)

0.496

-0.06 (-0.21 - 0.18)

0.870

   

HOMA-IR

1.66 (1.54 - 1.80)

-0.04 (-0.46 - 0.15)

0.309

0.02 (-0.30 - 0.49)

0.634

-0.11 (-0.32 - 0.93)

0.282

   

HOMA-B

85.09 (77.74 - 93.14)

0.05 (-0.06 - 0.27)

0.223

0.07 (-0.08 - 0.81)

0.106

-0.07 (-0.43 - 0.03)

0.091

   

US Cohort (n = 569)

rs231362

rs2237892

rs2237895

   
 

Trait Mean

β (95%CI)

p adjustedΨ

β (95%CI)

p adjusted

β (95%CI)

p adjusted

   

BMI (kg/m2)

26.19 (25.83 - 26.55)

0.07 (-.030 - 2.43)

0.124

0.09 (0.11 - 2.90)

0.034

0.07 (-0.08 - 1.34)

0.082

   

WHR

0.88 (0.87 - 0.89)

-0.02 (-0.04 - 0.00)

0.197

-0.04 (-0.26 - 0.10)

0.395

-0.04 (-0.05 - 0.01)

0.289

   

FBG (mg/dL)

95.95 (95.05 - 96.85)

-0.01 (-0.03 - 0.00)

0.086

0.04 (-0.02 - 0.06)

0.373

0.03 (-0.02 - 0.03)

0.536

   

INSULIN (IU/mL)

6.72 (6.37 - 7.09)

0.04 (-0.05 - 0.12)

0.393

0.01 (-0.99 - 1.19)

0.862

-0.09 (-0.15 - -0.05)

0.037

   

HOMA-IR

1.57 (1.49 - 1.66)

0.02 (-0.17 - 0.25)

0.704

0.02 (-0.20 - 0.34)

0.622

-0.11 (-0.30 - -0.03)

0.015

   

HOMA-B

79.71 (74.87 - 84.86)

0.09 (-0.01 - 0.25)

0.062

-0.03 (-0.43 - 0.20)

0.490

-0.13 (-0.37 - -0.06)

0.008

   

Meta-analysis (n = 1,617)

rs231362

rs2237892

rs2237895

 

Trait Mean

P(F)1

P(R)2

P(H)3

P(F)

P(R)

P(H)

P(F)

P(R)

P(H)

BMI (kg/m2)

26.23 (25.99 - 26.48)

0.856

0.849

0.051

0.640

0.990

0.010

0.463

0.463

0.670

WHR

0.91 (0.91 - 0.92)

0.840

0.840

0.445

0.396

0.396

0.932

0.118

0.118

0.399

FBG (mg/dL)

95.48 (94.84 - 96.12)

0.020

0.020

0.551

0.555

0.553

0.284

0.596

0.725

0.133

INSULIN (IU/mL)

7.09 (6.75 - 7.46)

0.467

0.653

0.032

0.012

0.488

0.003

0.248

0.248

0.539

HOMA-IR

1.62 (1.54 - 1.71)

0.689

0.689

0.738

0.078

0.630

0.001

0.616

0.616

0.680

HOMA-B

82.71 (78.06 - 87.63)

0.062

0.062

0.912

0.475

0.766

0.293

0.009

0.009

0.532

Ψ P values were adjusted for age, gender and BMI in the Punjabi cohort; age, gender, BMI and place of birth in US cohorts; Bonferroni p = 0.008; 1p-value for fixed effect; 2p-value for random effect; 3 p-value for heterogeneity; measures on serum insulin, HOMA-IR, and HOMA-B were available in 657 of 1,048 control individuals in the Punjabi cohort.