Punjabi Cohort (n = 2,355) | US Cohort (n = 710) | Combined (n = 3,065)** | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
SNP | Genotype | NG†(%) | T2D¥(%) | Odds Ratios (OR)* (95%CI) P-value | NG (%) | T2D (%) | Odds Ratios††(95%CI) P-value | NG (%) | T2D (%) | Odds Ratios††(95%CI) P-value |
rs231362 | GG | 559 (54) | 779 (60) | unadjusted 1.25 (1.09 - 1.43) | 328 (58) | 81 (57) | unadjusted 0.97 (0.72 - 1.29) | 887 (56) | 860 (60) | unadjusted 1.18 (1.05 - 1.33) |
GA | 395 (38) | 437 (34) | 0.001 | 191 (34) | 49 (35) | 0.823 | 586 (37) | 486 (34) | 0.005 | |
AA | 78 (8) | 71 (6) | adjusted 1.24 (1.08 - 1.43) | 42 (8) | 11 (8) | adjusted 1.04 (0.75 - 1.45) | 120 (7) | 82 (6) | adjusted 1.21 (1.06 - 1.37) | |
Ψ G/A | 0.73/0.27 | 0.78/0.22 | 0.002 | 0.75/0.25 | 0.75/0.25 | 0.798 | 0.74/0.26 | 0.77/0.23 | 0.004 | |
rs2237892 | CC | 982 (96.3) | 1259 (97.6) | unadjusted 1.49 (0.94 - 2.37) | 523 (93.9) | 133 (95.7) | unadjusted 1.48 (0.63 - 3.47) | 1505 (95.5) | 1392 (97.4) | unadjusted 1.74 (1.18 - 2.56) |
CT | 36 (3.5) | 30 (2.3) | 0.094 | 32 (5.7) | 6 (4.3) | 0.368 | 68 (4.3) | 36 (2.5) | 0.005 | |
TT | 1 (0.1) | 1 (0.1) | adjusted 1.44 (0.89 - 2.31) | 2 (0.4) | 0 (0) | adjusted 2.35 (0.88 - 6.30) | 3 (0.2) | 1 (0.1) | adjusted 1.53 (1.01 - 2.32) | |
C/T | 0.98/0.02 | 0.99/0.01 | 0.136 | 0.97/0.03 | 0.98/0.02 | 0.088 | 0.98/0.02 | 0.99/0.01 | 0.046 | |
rs2237895 | AA | 359 (35) | 410 (32) | unadjusted 1.11 (0.99 - 1.25) | 206 (38) | 40 (29) | unadjusted 1.32 (1.02 - 1.70) | 565 (36) | 450 (32) | unadjusted 1.15 (1.04 - 1.27) |
AC | 473 (46) | 610 (47) | 0.068 | 249 (45) | 67 (48) | 0.037 | 722 (46) | 677 (48) | 0.006 | |
CC | 188 (18) | 265 (21) | adjusted 1.14 (1.01-1.28) | 96 (17) | 32 (23) | adjusted 1.24 (0.93 - 1.66) | 284 (18) | 297 (20) | adjusted 1.15 (1.03 - 1.29) | |
A/C | 0.58/0.42 | 0.56/0.44 | 0.036 | 0.60/0.40 | 0.53/0.47 | 0.146 | 0.59/0.41 | 0.55/0.45 | 0.011 | |
Meta-analysis | ||||||||||
SNP | Risk Allele | P-value (Fixed Effect) | P-value (Random Effect) | OR (Fixed Effect) | OR (Random Effect) | P-value (Heterogeneity) | ||||
rs231362 | G | 0.009 | 0.390 | 1.15 | 1.11 | 0.114 | ||||
rs2237892 | C | 0.030 | 0.030 | 1.37 | 1.37 | 0.522 | ||||
rs2237895 | C | 0.018 | 0.021 | 1.14 | 1.14 | 0.313 |