The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers

Table 3 ALOX5AP, LTA4H and LTB4R SNPs and severe COPD (defined by GOLD stage 3 and 4) in smokers.

SNP	Location	Controls (n = 176)				GOLD 3 and 4 (n = 389)					Additive
		0	1	2	MAF	0	1	2	MAF	p-value	Odds ratio	95%CI
*ALOX5AP*
SG13S25 (G/A)	5'UTR	138	35	2	0.11	325	60	2	0.09	0.231	0.72	0.42-1.23
SG13S114 (T/A)	Intron 1	92	63	20	0.29	164	180	36	0.33	0.282	1.21	0.86-1.70
rs3803277 (C/A)	Intron 2	54	80	42	0.47	122	203	58	0.42	0.045	0.72	0.52-0.99
SG13S89 (G/A)	Intron 3	162	13	0	0.04	356	32	0	0.04	0.701	0.85	0.36-1.99
rs4468448 (C/T)	Intron 4	100	65	11	0.25	221	146	18	0.24	0.882	0.97	0.67-1.41
SG13S32 (C/A)	Intron 4	42	88	43	0.49	110	199	78	0.46	0.195	0.81	0.58-1.12
SG13S41 (A/G)	Intron 4	149	21	0	0.06	343	38	4	0.06	0.293	0.71	0.37-1.35
SG13S35 (G/A)	3'UTR	146	26	0	0.06	312	61	2	0.09	0.677	0.88	0.49-1.59
*LTA4H*
rs1978331 (T/C)	Intron 11	66	81	27	0.39	153	165	62	0.38	0.090	0.76	0.56-1.04
rs17677715 (T/C)	Intron 6	115	50	6	0.18	241	124	15	0.21	0.808	1.05	0.71-1.56
rs2660899 (G/T)	5'UTR	130	45	1	0.13	264	109	10	0.17	0.114	1.44	0.92-2.26
rs2540482 (T/C)	5'UTR	107	58	8	0.21	231	129	19	0.22	0.677	1.08	0.74-1.58
rs2660845 (A/G)	5'UTR	92	71	12	0.26	209	154	22	0.26	0.452	0.87	0.61-1.25
rs2540475 (C/T)	5'UTR	108	55	5	0.19	236	118	16	0.20	0.895	0.97	0.65-1.45
*LTB4R2*
rs2332320 (T/C)	5'UTR	130	34	5	0.13	287	81	8	0.13	0.523	1.17	0.73-1.86
rs11158635 (G/T)	5'UTR	100	57	9	0.23	235	131	16	0.21	0.195	0.77	0.52-1.15
rs2516564 (C/T)	5'UTR	104	59	9	0.22	238	130	15	0.21	0.195	0.77	0.52-1.14
*LTB4R1*
rs2224122 (C/G)	5'UTR	102	55	9	0.22	228	130	18	0.22	0.365	0.83	0.56-1.23
rs1046587 (G/A)	3'UTR	43	94	36	0.48	95	195	83	0.48	0.857	1.03	0.75-1.42
rs3181384 (C/T)	3'UTR	100	58	10	0.20	230	131	18	0.22	0.183	0.77	0.52-1.13

Logistic regression was used to compare genotype frequencies between smoking controls (n = 176) and GOLD stage 3/4 cases (n = 389) using the additive model with the covariates age, gender and pack-years. OR, odds ratio; 95% CI, 95% confidence interval. 0, 1 and 2 represent the number of major homozygote, heterozygote and minor homozygote genotype frequencies. Black bold indicated (p = ≤ 0.05).

ISSN: 1471-2350