The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers

Table 2 ALOX5AP, LTA4H and LTB4R SNPs and COPD susceptibility in smokers.

SNP	Location	Controls (n = 176)				COPD (n = 599)					Additive
		0	1	2	MAF	0	1	2	MAF	p-value	Odds ratio	95%CI
*ALOX5AP*
SG13S25 (G/A)	5'UTR	138	35	2	0.11	491	100	5	0.09	0.556	0.87	0.55-1.37
SG13S114 (T/A)	Intron 1	92	63	20	0.29	248	282	58	0.34	0.198	1.22	0.90-1.65
rs3803277 (C/A)	Intron 2	54	80	42	0.47	184	303	103	0.43	0.318	0.87	0.65-1.15
SG13S89 (G/A)	Intron 3	162	13	0	0.04	551	45	1	0.04	0.771	0.90	0.43-1.88
rs4468448 (C/T)	Intron 4	100	65	11	0.25	333	226	34	0.25	0.807	1.04	0.76-1.45
SG13S32 (C/A)	Intron 4	42	88	43	0.49	162	302	130	0.47	0.351	0.87	0.66-1.16
SG13S41 (A/G)	Intron 4	149	21	0	0.06	524	62	6	0.06	0.542	0.84	0.47-1.48
SG13S35 (G/A)	3'UTR	146	26	0	0.06	479	97	3	0.09	0.970	1.01	0.60-1.71
*LTA4H*
rs1978331 (T/C)	Intron 11	66	81	27	0.39	223	257	109	0.40	0.419	0.89	0.68-1.18
rs17677715 (T/C)	Intron 6	115	50	6	0.18	372	188	26	0.20	0.899	1.02	0.72-1.46
rs2660899 (G/T)	5'UTR	130	45	1	0.13	418	158	16	0.16	0.113	1.39	0.93-2.08
rs2540482 (T/C)	5'UTR	107	58	8	0.21	358	195	34	0.23	0.473	1.13	0.81-1.58
rs2660845 (A/G)	5'UTR	92	71	12	0.26	328	224	40	0.26	0.483	0.89	0.65-1.22
rs2540475 (C/T)	5'UTR	108	55	5	0.19	358	186	27	0.21	0.770	0.95	0.67-1.35
*LTB4R2*
rs2332320 (T/C)	5'UTR	130	34	5	0.13	440	124	13	0.13	0.977	1.01	0.67-1.52
rs11158635 (G/T)	5'UTR	100	57	9	0.23	367	193	26	0.21	0.165	0.78	0.55-1.11
rs2516564 (C/T)	5'UTR	104	59	9	0.22	372	193	25	0.21	0.169	0.79	0.56-1.11
*LTB4R1*
rs2224122 (C/G)	5'UTR	102	55	9	0.22	363	190	28	0.21	0.232	0.81	0.57-1.15
rs1046587 (G/A)	3'UTR	43	94	36	0.48	155	298	128	0.48	0.566	1.09	0.82-1.45
rs3181384 (C/T)	3'UTR	100	58	10	0.20	363	191	28	0.21	0.111	0.76	0.54-1.07

Logistic regression was used to compare genotype frequencies between smoking controls (n = 176) and total COPD cases (n = 599) using the additive model with the covariates age, gender and pack-years. OR, odds ratio; 95% CI, 95% confidence interval. 0, 1 and 2 represent the number of major homozygote, heterozygote and minor homozygote genotype frequencies.

ISSN: 1471-2350