TY - JOUR AU - Meyers, D. A. AU - Larj, M. J. AU - Lange, L. PY - 2004 DA - 2004// TI - Genetics of asthma and COPD. Similar results for different phenotypes JO - Chest VL - 126 UR - https://doi.org/10.1378/chest.126.2_suppl_1.105S DO - 10.1378/chest.126.2_suppl_1.105S ID - Meyers2004 ER - TY - JOUR AU - Kleeberger, S. R. AU - Peden, D. PY - 2005 DA - 2005// TI - Gene-environment interactions in asthma and other respiratory diseases JO - Annu Rev Med VL - 56 UR - https://doi.org/10.1146/annurev.med.56.062904.144908 DO - 10.1146/annurev.med.56.062904.144908 ID - Kleeberger2005 ER - TY - JOUR AU - Kostikas, K. AU - Gaga, M. AU - Papatheodorou, G. AU - Karamanis, T. AU - Orphanidou, D. AU - Loukides, S. PY - 2005 DA - 2005// TI - Leukotriene B4 in exhaled breath condensate and sputum supernatant in patients with COPD and asthma JO - Chest VL - 127 UR - https://doi.org/10.1378/chest.127.5.1553 DO - 10.1378/chest.127.5.1553 ID - Kostikas2005 ER - TY - JOUR AU - Montuschi, P. AU - Kharitonov, S. A. AU - Ciabattoni, G. AU - Barnes, P. J. PY - 2003 DA - 2003// TI - Exhaled leukotrienes and prostaglandins in COPD JO - Thorax VL - 58 UR - https://doi.org/10.1136/thorax.58.7.585 DO - 10.1136/thorax.58.7.585 ID - Montuschi2003 ER - TY - JOUR AU - Barnes, P. J. PY - 2003 DA - 2003// TI - New concepts in chronic obstructive pulmonary disease JO - Annu Rev Med VL - 54 UR - https://doi.org/10.1146/annurev.med.54.101601.152209 DO - 10.1146/annurev.med.54.101601.152209 ID - Barnes2003 ER - TY - JOUR AU - Ford-Hutchinson, A. W. AU - Bray, M. A. AU - Doig, M. V. AU - Shipley, M. E. AU - Smith, M. J. PY - 1980 DA - 1980// TI - Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes JO - Nature VL - 286 UR - https://doi.org/10.1038/286264a0 DO - 10.1038/286264a0 ID - Ford-Hutchinson1980 ER - TY - JOUR AU - Sehmi, R. AU - Wardlaw, A. J. AU - Cromwell, O. AU - Kurihara, K. AU - Waltmann, P. AU - Kay, A. B. PY - 1992 DA - 1992// TI - Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects JO - Blood VL - 79 ID - Sehmi1992 ER - TY - JOUR AU - Woolhouse, I. S. AU - Bayley, D. L. AU - Stockley, R. A. PY - 2002 DA - 2002// TI - Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8 JO - Thorax VL - 57 UR - https://doi.org/10.1136/thorax.57.8.709 DO - 10.1136/thorax.57.8.709 ID - Woolhouse2002 ER - TY - JOUR AU - Ogawa, Y. AU - Calhoun, W. J. PY - 2006 DA - 2006// TI - The role of leukotrienes in airway inflammation JO - J Allergy Clin Immunol VL - 118 UR - https://doi.org/10.1016/j.jaci.2006.08.009 DO - 10.1016/j.jaci.2006.08.009 ID - Ogawa2006 ER - TY - JOUR AU - Duroudier, N. P. AU - Tulah, A. S. AU - Sayers, I. PY - 2009 DA - 2009// TI - Leukotriene pathway genetics and pharmacogenetics in allergy JO - Allergy VL - 64 UR - https://doi.org/10.1111/j.1398-9995.2009.02015.x DO - 10.1111/j.1398-9995.2009.02015.x ID - Duroudier2009 ER - TY - JOUR AU - Helgadottir, A. AU - Manolescu, A. AU - Thorleifsson, G. AU - Gretarsdottir, S. AU - Jonsdottir, H. AU - Thorsteinsdottir, U. AU - Samani, N. J. AU - Gudmundsson, G. AU - Grant, S. F. AU - Thorgeirsson, G. PY - 2004 DA - 2004// TI - The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke JO - Nat Genet VL - 36 UR - https://doi.org/10.1038/ng1311 DO - 10.1038/ng1311 ID - Helgadottir2004 ER - TY - JOUR AU - Helgadottir, A. AU - Manolescu, A. AU - Helgason, A. AU - Thorleifsson, G. AU - Thorsteinsdottir, U. AU - Gudbjartsson, D. F. AU - Gretarsdottir, S. AU - Magnusson, K. P. AU - Gudmundsson, G. AU - Hicks, A. PY - 2006 DA - 2006// TI - A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction JO - Nat Genet VL - 38 UR - https://doi.org/10.1038/ng1692 DO - 10.1038/ng1692 ID - Helgadottir2006 ER - TY - JOUR AU - Devillier, P. AU - Baccard, N. AU - Advenier, C. PY - 1999 DA - 1999// TI - Leukotrienes, leukotriene receptor antagonists and leukotriene synthesis inhibitors in asthma: an update. Part I: synthesis, receptors and role of leukotrienes in asthma JO - Pharmacol Res VL - 40 UR - https://doi.org/10.1006/phrs.1998.0458 DO - 10.1006/phrs.1998.0458 ID - Devillier1999 ER - TY - JOUR AU - Snelgrove, R. J. AU - Jackson, P. L. AU - Hardison, M. T. AU - Noerager, B. D. AU - Kinloch, A. AU - Gaggar, A. AU - Shastry, S. AU - Rowe, S. M. AU - Shim, Y. M. AU - Hussell, T. PY - 2010 DA - 2010// TI - A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation JO - Science VL - 330 UR - https://doi.org/10.1126/science.1190594 DO - 10.1126/science.1190594 ID - Snelgrove2010 ER - TY - JOUR AU - Holloway, J. W. AU - Barton, S. J. AU - Holgate, S. T. AU - Rose-Zerilli, M. J. AU - Sayers, I. PY - 2008 DA - 2008// TI - The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility JO - Allergy VL - 63 UR - https://doi.org/10.1111/j.1398-9995.2008.01667.x DO - 10.1111/j.1398-9995.2008.01667.x ID - Holloway2008 ER - TY - JOUR AU - Stewart, C. E. AU - Hall, I. P. AU - Parker, S. G. AU - Moffat, M. F. AU - Wardlaw, A. J. AU - Connolly, M. J. AU - Ruse, C. AU - Sayers, I. PY - 2009 DA - 2009// TI - PLAUR polymorphisms and lung function in UK smokers JO - BMC Med Genet VL - 10 UR - https://doi.org/10.1186/1471-2350-10-112 DO - 10.1186/1471-2350-10-112 ID - Stewart2009 ER - TY - JOUR AU - Celli, B. R. AU - MacNee, W. PY - 2004 DA - 2004// TI - Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper JO - Eur Respir J VL - 23 UR - https://doi.org/10.1183/09031936.04.00014304 DO - 10.1183/09031936.04.00014304 ID - Celli2004 ER - TY - JOUR AU - Barrett, J. C. AU - Fry, B. AU - Maller, J. AU - Daly, M. J. PY - 2005 DA - 2005// TI - Haploview: analysis and visualization of LD and haplotype maps JO - Bioinformatics VL - 21 UR - https://doi.org/10.1093/bioinformatics/bth457 DO - 10.1093/bioinformatics/bth457 ID - Barrett2005 ER - TY - JOUR AU - Hao, L. AU - Sayers, I. AU - Cakebread, J. A. AU - Barton, S. J. AU - Beghe, B. AU - Holgate, S. T. AU - Sampson, A. P. AU - Holloway, J. W. PY - 2006 DA - 2006// TI - The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma JO - Clin Exp Allergy VL - 36 UR - https://doi.org/10.1111/j.1365-2222.2006.02511.x DO - 10.1111/j.1365-2222.2006.02511.x ID - Hao2006 ER - TY - JOUR AU - Sayers, I. AU - Barton, S. AU - Rorke, S. AU - Beghe, B. AU - Hayward, B. AU - Van Eerdewegh, P. AU - Keith, T. AU - Clough, J. B. AU - Ye, S. AU - Holloway, J. W. PY - 2003 DA - 2003// TI - Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma JO - Thorax VL - 58 UR - https://doi.org/10.1136/thorax.58.5.417 DO - 10.1136/thorax.58.5.417 ID - Sayers2003 ER - TY - JOUR AU - Sampson, A. P. AU - Siddiqui, S. AU - Buchanan, D. AU - Howarth, P. H. AU - Holgate, S. T. AU - Holloway, J. W. AU - Sayers, I. PY - 2000 DA - 2000// TI - Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast JO - Thorax VL - 55 UR - https://doi.org/10.1136/thorax.55.suppl_2.S28 DO - 10.1136/thorax.55.suppl_2.S28 ID - Sampson2000 ER - TY - JOUR AU - Tobin, D. M. AU - Vary, J. C. AU - Ray, J. P. AU - Walsh, G. S. AU - Dunstan, S. J. AU - Bang, N. D. AU - Hagge, D. A. AU - Khadge, S. AU - King, M. C. AU - Hawn, T. R. PY - 2010 DA - 2010// TI - The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans JO - Cell VL - 140 UR - https://doi.org/10.1016/j.cell.2010.02.013 DO - 10.1016/j.cell.2010.02.013 ID - Tobin2010 ER - TY - CHAP AU - Sims, A. M. AU - Damholt, A. AU - Knutsson, M. AU - Carlholm, M. AU - Carlsson, L. G. AU - Lofdahl, C. G. AU - Postma, D. S. AU - Semb, K. F. PY - 2010 DA - 2010// TI - Genes in the 5-Lipoxygenase (5-LO) pathway: association with COPD BT - The American Thoracic Society ID - Sims2010 ER - TY - JOUR AU - Keatings, V. M. AU - Collins, P. D. AU - Scott, D. M. AU - Barnes, P. J. PY - 1996 DA - 1996// TI - Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma JO - Am J Respir Crit Care Med VL - 153 UR - https://doi.org/10.1164/ajrccm.153.2.8564092 DO - 10.1164/ajrccm.153.2.8564092 ID - Keatings1996 ER - TY - JOUR AU - Sato, E. AU - Koyama, S. AU - Takamizawa, A. AU - Masubuchi, T. AU - Kubo, K. AU - Robbins, R. A. AU - Nagai, S. AU - Izumi, T. PY - 1999 DA - 1999// TI - Smoke extract stimulates lung fibroblasts to release neutrophil and monocyte chemotactic activities JO - Am J Physiol VL - 277 ID - Sato1999 ER - TY - JOUR AU - Weathington, N. M. AU - van Houwelingen, A. H. AU - Noerager, B. D. AU - Jackson, P. L. AU - Kraneveld, A. D. AU - Galin, F. S. AU - Folkerts, G. AU - Nijkamp, F. P. AU - Blalock, J. E. PY - 2006 DA - 2006// TI - A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation JO - Nat Med VL - 12 UR - https://doi.org/10.1038/nm1361 DO - 10.1038/nm1361 ID - Weathington2006 ER - TY - JOUR AU - Mancini, J. A. AU - Evans, J. F. PY - 1995 DA - 1995// TI - Cloning and characterization of the human leukotriene A4 hydrolase gene JO - Eur J Biochem VL - 231 UR - https://doi.org/10.1111/j.1432-1033.1995.tb20671.x DO - 10.1111/j.1432-1033.1995.tb20671.x ID - Mancini1995 ER - TY - JOUR AU - Jiang, X. AU - Zhou, L. AU - Wu, Y. AU - Wei, D. AU - Sun, C. AU - Jia, J. AU - Liu, Y. AU - Lai, L. PY - 2010 DA - 2010// TI - Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis JO - Chembiochem VL - 11 UR - https://doi.org/10.1002/cbic.200900788 DO - 10.1002/cbic.200900788 ID - Jiang2010 ER - TY - JOUR AU - Kohansal, R. AU - Martinez-Camblor, P. AU - Agusti, A. AU - Buist, A. S. AU - Mannino, D. M. AU - Soriano, J. B. PY - 2009 DA - 2009// TI - The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort JO - Am J Respir Crit Care Med VL - 180 UR - https://doi.org/10.1164/rccm.200901-0047OC DO - 10.1164/rccm.200901-0047OC ID - Kohansal2009 ER - TY - JOUR AU - Sayers, I. AU - Barton, S. AU - Rorke, S. AU - Sawyer, J. AU - Peng, Q. AU - Beghe, B. AU - Ye, S. AU - Keith, T. AU - Clough, J. B. AU - Holloway, J. W. PY - 2003 DA - 2003// TI - Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population JO - Clin Exp Allergy VL - 33 UR - https://doi.org/10.1046/j.1365-2222.2003.01733.x DO - 10.1046/j.1365-2222.2003.01733.x ID - Sayers2003 ER - TY - JOUR AU - Sayers, I. AU - Sampson, A. P. AU - Ye, S. AU - Holgate, S. T. PY - 2003 DA - 2003// TI - Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene JO - Eur J Hum Genet VL - 11 UR - https://doi.org/10.1038/sj.ejhg.5201015 DO - 10.1038/sj.ejhg.5201015 ID - Sayers2003 ER - TY - STD TI - Obeidat M, Wain LV, Shrine N, Kalsheker N, Artigas MS, Repapi E, Burton PR, Johnson T, Ramasamy A, Zhao JH, et al: A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample. PLoS One. 6 (5): e19382- ID - ref32 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/12/173/prepub UR - http://www.biomedcentral.com/1471-2350/12/173/prepub ID - ref33 ER -