Table 1 Distribution of metaphases obtained from 72-hour cultures of peripheral blood lymphocytes, according to the number of chromosomes and the presence of secondary aberrations derived from the ring chromosomes.
From: Mechanisms of ring chromosome formation, ring instability and clinical consequences
Patients Metaphases | I r(3) | II r(4) | III r(10) | IV r(10) | V r(13) | VI r(13) | VII r(14) | VIII r(15) | IX r(18) | X r(18) | XI r(18) | XII r(22) | XIII r(22) | XIV r(22) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
46 chromosomes with a ring | 262 | 287 | 251 | 253 | 271 | 264 | 260 | 277 | 268 | 275 | 272 | 276 | 288 | 285 |
45 chromosomes without ring | 19 | 5 | 38 | 33 | 12 | 19 | 35 | 11 | 17 | 17 | 20 | 15 | 11 | 13 |
Secondary aberrations | 19 | 8 | 11 | 14 | 17 | 17 | 5 | 12 | 15 | 8 | 8 | 9 | 1 | 2 |
Total | 300 | 300 | 300 | 300 | 300 | 300 | 300 | 300 | 300 | 300 | 300 | 300 | 300 | 300 |
Percentage of cells with secondary aberrations and without the ring (%) | 12.7 | 4.3 | 16.3 | 15.7 | 9.6 | 12.0 | 13.3 | 7.7 | 10.7 | 8.3 | 9.3 | 8.0 | 4.0 | 5.0 |