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Table 4 Additional genotyping at 17q12 to localize association signal

From: Genome-wide association study identifies PERLD1 as asthma candidate gene

SNPa

Variationb

Genec

Cased

Controle

Multiplicativef

Regressiong

rs12601930

(T/C)

PPP1R1B

0.188

0.179

5.59 × 10-1

1.061 (0.876-1.284)

5.73 × 10-1

0.944 (0.771-1.155)

rs9532

(T/C)

PPP1R1B

0.001

0.001

1.00

1.007 (0.063-16.118)

9.54 × 10-1

1.085 (0.066-17.84)

rs1877031

(T/C)

STARD3

0.346

0.401

2.96 × 10-3

0.792 (0.679-0.924)

1.96 × 10-1

1.419 (0.835-2.412)

rs876493

(T/C)

PNMT

0.266

0.305

2.37 × 10-2

0.825 (0.700-0.973)

4.50 × 10-1

1.111 (0.846-1.460)

rs2941504

(A/G)

PERLD1

0.305

0.359

9.56 × 10-6

0.745 (0.654-0.848)

NA

rs1136201

(G/A)

ERBB2

0.097

0.123

3.03 × 10-2

0.768 (0.606-0.974)

5.89 × 10-1

0.930 (0.715-1.210)

rs1058808

(G/C)

ERBB2

0.325

0.389

7.81 × 10-4

0.756 (0.644-0.889)

9.00 × 10-2

0.652 (0.398-1.069)

  1. The genotyped SNPs are sorted according to chromosomal position at 17q12 (not shown).
  2. a) The SNP rsID; b) The polymorphism in the format (minor allele/ancestral allele); c) Gene name; d) & e) Minor allele frequencies in case and control samples respectively; f) P value obtained from a Fisher's test for a multiplicative genetic model together with allelic odds ratio and 95% confidence interval calculated from allele counts using the minor allele as the reference; g) P value obtained from a logistic regression analysis of allelic association using PERLD1 SNP rs2941504 as a covariate together with odds ratio and 95% confidence interval from the regression.