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Table 2 Genotyping results of 19 SNPs in discovery phase

From: Genome-wide association study identifies PERLD1 as asthma candidate gene

SNPa

Geneb

CHB MAFc

P Pool A d

P Pool B e

P Pool C f

P Pool D g

No. of poolsh

rs2941504

PERLD1

0.456

7.82 × 10-6

*3.06 × 10-8

*3.94 × 10-13

*1.78 × 10-10

3

rs6036630

-

0.189

*2.64 × 10-9

*3.76 × 10-9

2.86 × 10-2

4.51 × 10-1

2

rs2304368

R3HDM1

0.056

*1.63 × 10-11

*9.58 × 10-9

1.55 × 10-5

2.79 × 10-2

2

rs12590520

-

0.389

1.00

*1.46 × 10-9

*8.66 × 10-9

5.50 × 10-1

2

rs11895665

-

0.267

*2.23 × 10-9

*6.53 × 10-9

2.08 × 10-1

1.30 × 10-1

2

rs10520302

GPM6A

0.378

*1.21 × 10-8

1.16 × 10-3

8.26 × 10-1

*2.31 × 10-9

2

rs11225634

DYNC2H1

0.122

5.03 × 10-1

*1.57 × 10-8

9.40 × 10-2

*2.97 × 10-14

2

rs7930326

-

0.200

*8.92 × 10-9

5.12 × 10-2

*2.06 × 10-10

8.89 × 10-1

2

rs12601246

SMYD4

0.057

*1.07 × 10-9

6.89 × 10-2

7.69 × 10-1

*1.60 × 10-8

2

rs4738955

NKAIN3

0.081

*5.78 × 10-15

3.36 × 10-1

*2.11 × 10-13

1.82 × 10-1

2

rs8133478

RUNX1

0.078

1.94 × 10-1

*9.57 × 10-9

1.35 × 10-1

*6.39 × 10-11

2

rs9292197

PDE4D

0.189

7.97 × 10-1

9.32 × 10-1

*1.05 × 10-10

*1.19 × 10-8

2

rs11904654

LTBP1

0.478

5.85 × 10-1

*3.39 × 10-9

5.89 × 10-1

*1.16 × 10-8

2

rs11948993

-

0.341

*1.15 × 10-9

3.27 × 10-5

*6.49 × 10-9

3.60 × 10-1

2

rs6788482

-

0.341

2.20 × 10-1

*9.58 × 10-9

8.17 × 10-1

*5.29 × 10-9

2

rs6793110

LRIG1

0.056

*2.43 × 10-11

7.26 × 10-6

*6.99 × 10-9

4.82 × 10-5

2

rs10917042

USP48

0.433

*2.75 × 10-11

1.60 × 10-1

5.73 × 10-2

*1.50 × 10-9

2

rs2268451

TSHR

0.279

2.84 × 10-1

*2.47 × 10-8

*5.52 × 10-9

1.16 × 10-1

2

rs5993853

TXNRD2

0.156

4.33 × 10-1

*6.11 × 10-9

2.44 × 10-1

*1.30 × 10-8

2

  1. a) The SNP rsID; b) Gene name or hyphen if intergenic; c) SNP minor allele frequency in Hapmap CHB population; d)-g) P values obtained from a Z-test of estimated allele frequencies of case vs control in pools A-D (These P values were solely used to rank the SNPs for replication and weren't considered to be indicative of the strength of association.); h) The number of pool sets in which SNP was ranked below a Bonferroni-corrected P value of 5.52 × 10-8 (P values indicated with a *)