Table 1 General features of control and PHPT subjects
Control group | PHPT group | p | |
|---|---|---|---|
(n = 114+) | (n = 298) | ||
Age (years) | 59 ± 13 | 62 ±13 | 0.052 |
♀/♂ | 5/1 | 5.6/1 | 0.661 |
Menopause ♀ (%) | 87.2 | 89.5 | 0.536 |
BMI (kg/m2) | 25.3 ± 3.8 | 28.7 ± 5.0 | 0.000 |
Fracture (%) | 21 | 24.6 | 0.000 |
Renal lithiasis (%) | 6 | 36.0 | 0.000 |
25-OH-VitD (ng/mL ) | 20.4 (6-42) | 17.2 ± (3-93) | 0.997 |
25-OH-VitD ≥ 30 ng/mL (%) | 15.2 | 9.2 | 0.221 |
Creatinine (mg/dL) | 0.98 ± 0.14 | 1,02 ± 0.29 | 0.179 |
Total Calcium (mg/dL) | 9.4 (8.6-10.6) | 10.7 (9.8-14.5) | 0.000 |
Ionized Calcium (mM) | 1.23 (1.11-1.36) | 1.47 (1.25-2.07) | 0.000 |
PTH (pg/mL) | 37 (10-105) | 179 (59-1279) | 0.000 |
Alk Phosphatase (U/L) | 63.4 (33-198) | 82.3 (20-373) | 0.000 |
B Alk Phosphatase (U/L) | 22.1 (11-53) | 32.9 (5-85) | 0.000 |
P1NP (μg/L) | 46.3 (15-145) | 54.9 (11-255) | 0.005 |
Crosslaps B (ng/mL) | 0.475 (0.053-1.460) | 0.814 (0.044-3.208) | 0.000 |
Osteocalcin (ng/mL) | 19.4 (6-39) | 30.9 (7-175) | 0.000 |
Serum OPG (pmol/L) | 3.0 (0.89-5.61) | 4.8 (0.01-12.42) | 0.000 |
LS_BMD (g/cm2) | 0.935 ± 0.134 | 0.879 ± 0.155 | 0.000 |
FemNeck_BMD (g/cm2) | 0.749 ± 0.120 | 0.691 ± 0.104 | 0.000 |
TotHip_BMD (g/cm2) | 0.887 ± 0.126 | 0.840 ± 0.145 | 0.000 |
Rad 1/3_BMD (g/cm2) | 0.671 ± 0.696 | 0.629 ± 0.102 | 0.000 |