Table 5 Clinical characteristics of subjects with rare ZNF750 variants in the 5' regulatory region
From: Association analysis identifies ZNF750 regulatory variants in psoriasis
ZNF750Variant | # Pso Cases | Age: Study Entry (Onset) | Gender | PsA | Family History of Psoriasis | Description |
|---|---|---|---|---|---|---|
c.-458G>A | 1 | NA | Female | Yes | Sister | Confirmed psoriasis, no other information available |
c.-261G>A | 1 | 57 (35) | Male | No | Mother, brother, daughter, niece, nephew | Confirmed psoriasis |
c.-233C>T | 4 | 41 (25) | Female | No | Mother, sister | Plaque and inverse psoriasis affecting scalp, trunk, extremities, breast folds, axillae, and genitals. |
| Â | Â | 32 (15) | Female | No | Mother | Plaque psoriasis with 10-20% BSA affecting scalp, trunk, arms, legs |
| Â | Â | 34 (5) | Male | No | Father, sister | Guttate psoriasis affecting the scalp, trunk, and arms with 5-10% BSA |
| Â | Â | 54 (35) | Female | No | Sister | Plaque psoriasis affecting elbows, knees, and legs with 10-20% BSA |
c.-232G>A | 1 | 43 (30) | Male | No | Maternal cousin | Moderate plaque and inverse psoriasis affecting scalp, elbows, legs, axillae, genitals, and nails |
c.-45G>C | 1 | 30 (5) | Female | No | Father | Moderate guttate (originally plaque) and inverse psoriasis affecting scalp, arms, legs, trunk, axillae, and genitals |
c.-36A>G | 1 | 40 (25) | Female | No | Sister | Moderate psoriasis affecting trunk, legs |
c.-32G>A | 1 | 65 (NA) | Male | No | NA | Confirmed psoriasis |