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Table 3 Haplotype association testing between cases and controls

From: Association analysis identifies ZNF750 regulatory variants in psoriasis

Haplotype

Hap Freq

F_case

F_control

P Value

Emp P-Val

Odds Ratio [95% CI]

CCACCCGT

0.374

0.354

0.41

0.0106

0.0311

0.79 [0.66-0.94]

CCACCTA(-)

0.246

0.253

0.234

0.3321

0.9359

-

ACACCTA(-)

0.137

0.138

0.136

0.9158

1.0000

-

CTGCCTA(-)

0.089

0.091

0.085

0.6426

0.9995

-

CTGTCTA(-)

0.089

0.091

0.086

0.7198

0.9997

-

ACACTTA(-)

0.02

0.02

0.02

0.9666

1.0000

-

CCACCCG(-)

0.019

0.026

0.006

0.0011

0.0024

3.70 [1.45-9.46]

  1. The eight marker haplotype, as ordered in the table, consists of: rs3744165, rs12450046, rs8074277, rs35653278, rs34188981, rs12948179, rs12938126, rs35156590. Hap Freq, overall haplotype frequency; F_case, haplotype frequency in cases; F_control, haplotype frequency in controls; Emp P-Val, empiric p-value calculated by permutation testing.