Association analysis identifies ZNF750 regulatory variants in psoriasis

BMC Medical Genetics

Table 1 Common variants identified in ZNF750

Name	Position	Property (PolyPhen2 impact)	Alleles	F_case	F_control	Fisher P
rs3744165	78383731	Exon 2, 5' UTR	C/A	0.171	0.161	0.541
rs12450046	78383677	Exon 2, 5' UTR	C/T	0.186	0.172	0.478
rs8074277	78382917	Exon 2, M235V (benign)	A/G	0.189	0.18	0.640
rs35653278	78382757	Exon 2, P288L (probably)	C/T	0.092	0.09	0.937
rs34188981	78382558	Exon 2, T354T	C/T	0.021	0.021	1.000
rs12948179	78381781	Exon 3, P566P	T/C	0.393	0.42	0.233
rs12938126	78381754	Exon 3, A575A	A/G	0.392	0.42	0.232
rs71918228	78381176-79	Exon 3, 3' UTR	CAAA/-	0.465	0.478	0.586
rs35156590	78380584	3' Downstream	-/T	0.369	0.418	0.028

Common variants are defined as those with minor allele frequency (MAF) ≥ 2% in controls. Position is on Chr17 (hg18). UTR, untranslated region. PolyPhen2 impact given as benign, possibly damaging, or probably damaging. Alleles are given as major/minor on the (-) strand. F_case, MAF in cases; F_control, MAF in controls.

ISSN: 1471-2350