Figure 1
From: Association analysis identifies ZNF750 regulatory variants in psoriasis
ZNF750 gene structure and variants. ZNF750 consists of 3 exons, with the translation start site within exon 2. Narrow boxes indicate 5' and 3' untranslated regions; wider boxes indicate translated regions. ZNF750 contains two nuclear localization sites (NLS) and a C2H2 zinc finger domain (ZNF). Arrows depict the locations of a deleterious frameshift mutation seen in a Jewish Moroccan family (56_57dupCC), promoter and 5' UTR variations examined in this study (c.-625A>C, c.-458G>A, c.-261G>A, c.-233 C>T, c.-232G>A), and start sites of ZNF750 mRNA isoforms A and B.