Association of common variants in JAK2 gene with reduced risk of metabolic syndrome and related disorders

BMC Medical Genetics

Table 2 Association between individual JAK2 SNPs, Metabolic Syndrome and related phenotypes

	MS negative	MS positive	OR (IC 95%)	p	p^a	p^b
rs7849191
TT vs. TC vs. CC	69 vs. 241 vs. 226	38 vs. 76 vs. 57	-	0.009	ns	ns
CC + CT vs. TT	467 vs. 69	133 vs. 38	0.517 (0.333-0.803)	0.005	0.001	0.002
CC vs. CT + TT	226 vs. 310	57 vs. 114	0.686 (0.478-0.984)	0.048	0.011	0.034
rs3780378
TT vs. TC vs. CC	149 vs. 269 vs. 121	33 vs. 83 vs. 57	-	0.008	0.002	ns (0.096)
TT +TC vs. CC	418 vs. 121	116 vs. 57	0.589 (0.404-0.858)	0.006	0.001	0.007
TT vs. TC+ CC	149 vs. 390	33 vs. 140	0.617 (0.404-0.942)	0.027	0.020	0.022
	HTG negative	HTG positive	OR (IC 95%)	p	p ^a	p ^b
rs3780378
TT vs. TC vs. CC	139 vs. 250 vs. 108	48 vs.108 vs. 71	-	0.013	0.006	ns (0.082)
TT +TC vs. CC	389 vs. 108	136 vs. 71	0.610 (0.429-0.868)	0.007	0.002	0.011
TT vs. TC+ CC	139 vs. 358	48 vs. 179	-		ns	ns
	HW negative	HW positive	OR (IC 95%)	p	p ^a	p ^b
rs3780378
TT vs. TC vs. CC	145 vs. 257 vs. 118	41 vs.101 vs. 61	-	0.037	0.021	ns (0.082)
TT +TC vs. CC	402 vs. 118	142 vs. 61	0.683 (0.475-0.983)	0.044	0.016	ns (0.07)
TT vs. TC+ CC	145 vs. 375	41 vs. 172	0.655 (0.442-0.969)	0.037	0.033	ns (0.05)

^a Age adjusted; ^b Age and BMI adjusted. MS = metabolic syndrome; HTG = Hypertriglyceridemia; HW = hypertriglyceridemic waist; ns = not significant.

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