Figure 3
From: A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Chinese patients
Structural modeling of the wild-type and mutant proteins. The STK11 protein is mainly comprised of three major domains: the N-terminal non-catalytic domain in red, the catalytic kinase domain in green, and the C-terminal non-catalytic regulatory domain in blue. The mutation, p.Q302X, leads to partial loss of the kinase domain and complete loss of the C-terminal end of the α-helix.