Table 2 Putative antagonistically pleiotropic disease alleles.
From: Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles
Disease | Gene; Variation | Putative Benefit |
|---|---|---|
Triosephosphate Isomerase Deficiency | TPI Gene: point mutations. | Reduction in oxidative stress. |
Tay Sachs | HEXA: missense mutations. | Protection against tuberculosis. |
Hemachromatosis | HFE Gene: many point mutation. | Better iron absorption, increased resistance to typhoid fever and tuberculosis |
Phenylketonuria | PKU: missense mutation. | Lower probability of miscarriage |
Leukemia | PTNP11: various expression level mutations. | Lower probability of hepatocellular carcinoma |
Schizophrenia | Chromosomal regions 6p22-p24 and 11q21-22. | Higher relative fertility (in unaffected relatives). |
Cancer | TNFRSF11B Gene; Various Polymorphisms | Increased Bone Density in Females |