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Table 4 Early life endotoxin exposure and Eczema by age 6: Effect modification by genetic polymorphisms in the endotoxin/TLR signaling pathway† (P values for interaction term shown)*

From: Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1

Gene

SNP†

Genotype

OR (95%CI) for quartile increase in endotoxin

p-value for Interaction (SNP*Endotoxin Quartile)

CD80

rs7630595

GG

GA/AA

1.11 (0.85 to 1.44)

0.57 (0.24 to 1.32)

0.03

IRAK2

rs263408

TT

TC/CC

0.87 (0.67 to 1.11)

1.80 (0.74 to 4.37)

0.02

CD80

rs13071247

AA

AC/CC

1.14 (0.87 to 1.49)

0.64 (0.29 to 1.40)

0.03

CD80

rs6808536

GG

GT/TT

1.08 (0.82 to 1.42)

0.74 (0.34 to 1.61)

0.14

STAT4

rs925847

CC

CT/TT

1.07 (0.78 to 1.47)

0.90 (0.42 to 1.94)

0.45

  1. †SNPs tested for interaction were previously associated with eczema in this cohort *Model adjusted for daycare, maternal eczema, breastfeeding, income level, cohort and sex