Table 2 Early life endotoxin exposure and asthma by age 6: Effect modification by genetic polymorphisms in the endotoxin/TLR signaling pathway†(P values for interaction term shown)*
Gene | SNP †| Genotype | OR (95%CI) for quartile increase in endotoxin | p-value for Interaction (SNP*Endotoxin Quartile) |
|---|---|---|---|---|
ACAA1 (near MYD88) | rs156265 | CC CG/GG | 1.21 (0.92 to 1.57) 0.39 (0.15 to 1.01) | 0.0013 |
LY96 | rs16938758 | AA AT/TT | 1.00 (0.77 to 1.30) 1.16 (0.52 to 2.55) | 0.59 |
DEFB1 | rs5743404 | TT TC/CC | 1.24 (0.83 to 1.85) 0.95 (0.39 to 2.30) | 0.28 |
IFNG | rs2069718 | CC CT/TT | 1.02 (0.69 to 1.49) 1.02 (0.43 to 2.42) | 0.98 |
CARD15 | rs5743291 | GG GA/AA | 1.09 (0.84 to 1.42) 0.96 (0.41 to 2.25) | 0.67 |
TGFB1 | rs12980942 | GG GA/AA | 1.04 (0.79 to 1.38) 0.96 (0.44 to 2.09) | 0.75 |
TGFB1 | rs6957 | AA AG/GG | 1.04 (0.78 to 1.39) 0.97 (0.45 to 2.09) | 0.77 |